PMID: 15384026Sep 24, 2004Paper

Effects of an ACE inhibitor or angiotensin receptor blocker on potassium in CAPD patients

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Bunyong Phakdeekitcharoen, Pornthep Leelasa-nguan

Abstract

Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) have shown numerous benefits to the cardiovascular system. However, using both drugs is associated with hyperkalemia, especially in end-stage renal disease (ESRD) patients. To the authors' knowledge, there has been no prospective systematic study of the safety and potassium homeostasis of both drugs in continuous ambulatory peritoneal dialysis (CAPD) patients. Twenty-nine stable, normokalemic CAPD patients without potassium-interference drugs were selected randomly to receive, for 4-week periods, 8 mg candesartan or 10 mg enalapril daily. After completion of the initial drug, both treatment groups were crossed. Twenty-one patients completed the study. Baseline blood pressure, serum potassium level, plasma aldosterone, adequacy of dialysis, and residual renal function were not different between both groups. For the total group, serum potassium changes were not significantly different between baseline and at 4 weeks after treatment in both groups. The incidence of hyperkalemia (potassium > or =5.5 mEq/L [mmol/L]) was 13% and not different between groups. Nine of 11 events of hyperkalemia were associated with Kt/V urea less than 2, and 8 of ...Continue Reading

Citations

Oct 1, 2013·Seminars in Dialysis·Sarah SanghaviJaime Uribarri
Sep 10, 2014·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Somchai YongsiriPakaphan Dinchuthai
Jun 6, 2009·Therapeutic Advances in Cardiovascular Disease·Hiromichi Suzuki
Feb 2, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Adrian CovicDavid J A Goldsmith
Mar 24, 2011·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Peter G BlakeUNKNOWN Canadian Society of Nephrology Work Group on Adequacy of Peritoneal Dialysis

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