PMID: 2107958Feb 1, 1990Paper

Effects of an amino acid solution enriched with either branched chain amino acids or ornithine-alpha-ketoglutarate on the postoperative intracellular amino acid concentration of skeletal muscle

The British Journal of Surgery
F HammarqvistE Vinnars

Abstract

Patients undergoing elective cholecystectomy provide a highly reproducible model of the effects of trauma on intermediary metabolism. Three parenteral nutrition regimens were given to groups of eight such patients. An isonitrogenous total parenteral nutrition, including a commercially available amino acid solution, an amino acid solution enriched with branched chain amino acids or one supplemented with ornithine-alpha-ketoglutarate, was given after operation. The intra cellular free amino acid concentrations of skeletal muscle were determined in tissue specimens obtained before operation and on the third postoperative day using a percutaneous needle biopsy technique. The mean (s.e.m.) decrease in the concentrations of free intracellular glutamine on the third postoperative day was less pronounced (P less than 0.05) in the ornithine-alpha-ketoglutarate group (18.8(7.5)per cent) than in the control group (39.4(5.1)per cent) or the branched chain amino acid group (45.3(6.1)per cent). In conclusion, in the immediate postoperative period total parenteral nutrition supplemented with ornithine-alpha-ketoglutarate countered the decline in the muscle free glutamine. No difference in this parameter was seen between the control group and ...Continue Reading

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Citations

Mar 24, 1990·Lancet·J WernermanE Vinnars
Mar 24, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Folke HammarqvistJan Wernerman
Aug 11, 2000·Journal of Gastroenterology and Hepatology·C PlatellJ C Hall
Jan 1, 1995·Nutrition Research Reviews·K R GardinerB J Rowlands
Jan 1, 1997·Critical Care Medicine·F HammarqvistJ Wernerman
May 1, 1993·Clinical Physiology·J WernermanE Vinars
Mar 4, 1995·Lancet·U KjellmanJ Wernerman
Sep 8, 2010·The Journal of Nutrition, Health & Aging·S Walrand
Jun 1, 1997·The Annals of Thoracic Surgery·U W KjellmanJ Wernerman
Jan 14, 2016·Biomolecules & Therapeutics·Nan WuDiyan Li
Jun 1, 1991·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M JeevanandamW R Schiller
Aug 11, 2005·Metabolism: Clinical and Experimental·Cécile LoïLuc Cynober
Aug 28, 2010·Journal of Nutrition and Metabolism·Folke HammarqvistJan Wernerman
Jun 22, 2016·Archivum Immunologiae Et Therapiae Experimentalis·Barbara ZdzisińskaMartyna Kandefer-Szerszeń
Nov 14, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Olivier Le BacquerDominique Darmaun
Feb 13, 2001·Clinical Physiology·F HammarqvistJ Wernerman
Feb 1, 1990·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J WernermanE Vinnars
Jun 1, 1995·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·D Boggio BertinetF Balzola
Apr 17, 1999·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·F HammarqvistJ Wernerman
Mar 1, 1993·JPEN. Journal of Parenteral and Enteral Nutrition·V R Preedy, P J Garlick
Sep 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·M VaubourdolleL Cynober
Jul 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·E VinnarsJ Wernerman
Aug 3, 2018·Journal of the International Society of Sports Nutrition·Chad M KerksickRichard B Kreider
Dec 9, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Erica P A RuttenNicolaas E P Deutz
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·J P De Bandt, L A Cynober
Feb 1, 1995·The British Journal of Nutrition·J P De BandtJ Giboudeau
Jul 1, 1994·JPEN. Journal of Parenteral and Enteral Nutrition·B PeterssonJ Wernerman
Apr 1, 1995·Nutrition Reviews·R V Varanasi, J R Saltzman
Oct 1, 1990·The Proceedings of the Nutrition Society·D B Silk, J J Payne-James
Jan 1, 1995·Annales Françaises D'anesthèsie Et De Rèanimation·L Cynober

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