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Effects of an aminosteroid, ORG 6001, on various membrane phenomena of non-myelinated nerve fibres of the rat

European Journal of Pharmacology

May 1, 1978

J H KingmaA D Hertog

Abstract

The aminosteroid ORG 6001 (3 alpha-amino-5 alpha-androstan-2 beta-ol-17-one hydrochloride) was shown to be a compound with a rather strong local anaesthetic action. Compound action potentials evoked in non-myelinated nerve fibres of the desheathed rat vagus with the single sucrose gap m...read more

Mentioned in this Paper

Cerebellar Mossy Fibers
Myelin Sheath
Resting Potentials
Potassium
Action Potentials
Anti-Arrhythmia Agents
Sodium Pump Activity
Antiarrhythmic [EPC]
Plant fiber
Vagus Nerve Structure
Paper Details
References
  • References6
  • Citations4
1
  • References6
  • Citations4
1

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Effects of an aminosteroid, ORG 6001, on various membrane phenomena of non-myelinated nerve fibres of the rat

European Journal of Pharmacology

May 1, 1978

J H KingmaA D Hertog

PMID: 658128

DOI: 10.1016/0014-2999(78)90224-8

Abstract

The aminosteroid ORG 6001 (3 alpha-amino-5 alpha-androstan-2 beta-ol-17-one hydrochloride) was shown to be a compound with a rather strong local anaesthetic action. Compound action potentials evoked in non-myelinated nerve fibres of the desheathed rat vagus with the single sucrose gap m...read more

Mentioned in this Paper

Cerebellar Mossy Fibers
Myelin Sheath
Resting Potentials
Potassium
Action Potentials
Anti-Arrhythmia Agents
Sodium Pump Activity
Antiarrhythmic [EPC]
Plant fiber
Vagus Nerve Structure

Similar Papers Found In These Feeds

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Related Papers

European Journal of Pharmacology

Antiarrhythmic and hemodynamic effects of an aminosteroid (Org 3001) in the digitalized dog

European Journal of PharmacologyMarch 1, 1976
W J RemmeF Hagemeyer
Paper Details
References
  • References6
  • Citations4
1
  • References6
  • Citations4
1
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