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Effects of an aminosteroid, ORG 6001, on various membrane phenomena of non-myelinated nerve fibres of the rat

European Journal of Pharmacology

May 1, 1978

Jan Herre KingmaA D Hertog

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Abstract

The aminosteroid ORG 6001 (3 alpha-amino-5 alpha-androstan-2 beta-ol-17-one hydrochloride) was shown to be a compound with a rather strong local anaesthetic action. Compound action potentials evoked in non-myelinated nerve fibres of the desheathed rat vagus with the single sucrose gap m...read more

Mentioned in this Paper

Org 6001
Potassium
Local Anesthetics
Cardiac Conduction
Fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether
Sodium
Potassium Measurement
Metazoa
17-Ketosteroids
Lidocaine Monohydrochloride, Monohydrate
Paper Details
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Effects of an aminosteroid, ORG 6001, on various membrane phenomena of non-myelinated nerve fibres of the rat

European Journal of Pharmacology

May 1, 1978

Jan Herre KingmaA D Hertog

PMID: 658128

DOI: 10.1016/0014-2999(78)90224-8

Abstract

The aminosteroid ORG 6001 (3 alpha-amino-5 alpha-androstan-2 beta-ol-17-one hydrochloride) was shown to be a compound with a rather strong local anaesthetic action. Compound action potentials evoked in non-myelinated nerve fibres of the desheathed rat vagus with the single sucrose gap m...read more

Mentioned in this Paper

Org 6001
Potassium
Local Anesthetics
Cardiac Conduction
Fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether

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Paper Details
References

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