Effects of an AMPA receptor modulator on methamphetamine-induced hyperactivity in rats

Brain Research
J LarsonGary Lynch

Abstract

The present study tested if a positive modulator of AMPA-type glutamate receptors would counteract the behavioral effects of a drug that enhances the release of dopamine. BDP-29, a compound shown to increase AMPA receptor-mediated synaptic responses in hippocampal slices, markedly attenuated the amount of stereotypic rearings seen in rats after methamphetamine injections. These results suggest that AMPA receptor modulators ameliorate certain aberrant, dopamine-related behaviors and hence may be of interest with regard to schizophrenia.

References

Jun 1, 1990·Trends in Pharmacological Sciences·H Wachtel, L Turski
Jan 1, 1973·The American Journal of Psychiatry·S H Snyder
Jul 1, 1984·Pharmacology, Biochemistry, and Behavior·A Robertson, C MacDonald
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·U StaubliG Lynch
Mar 1, 1996·International Clinical Psychopharmacology·G LynchR S Schehr

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Citations

Mar 17, 2004·Current Opinion in Pharmacology·Gary Lynch
Apr 27, 2011·Molecular Psychiatry·P W Kalivas, N D Volkow
Aug 29, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tatiana LipinaJohn Roder
Nov 23, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Elke WezenbergBernard G C Sabbe
Dec 5, 2000·Behavioural Pharmacology·B Scatton, D J Sanger
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Guochuan Tsai, Joseph T Coyle
May 31, 2007·Clinical Drug Investigation·Pietro GareriGiovambattista De Sarro
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·R R GainetdinovM G Caron
Aug 8, 2006·Trends in Neurosciences·Gary Lynch, Christine M Gall
Nov 15, 2006·Neuropharmacology·Oliver P VossJames McCulloch
Mar 3, 2004·Mental Retardation and Developmental Disabilities Research Reviews·Elizabeth Berry-Kravis, Kristina Potanos
Aug 20, 2005·Addiction Biology·Makoto FukumotoRyuzou Kawahara
Nov 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Amy C AraiMarkus Kessler
Oct 11, 2001·Journal of Clinical Psychopharmacology·D C GoffG Lynch

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