PMID: 6408271May 1, 1983Paper

Effects of an anabolic steroid on plasma amino acids, proteins, and body composition in patients receiving intravenous hyperalimentation

JPEN. Journal of Parenteral and Enteral Nutrition
G A YoungG L Hill

Abstract

In this controlled trial we have studied the effect of anabolic steroid on ill surgical patients receiving intravenous hyperalimentation. Body composition, plasma proteins, and amino acids were compared in each of two groups of 12 patients before and after 14 days of intravenous feeding. The patients in one group were given 100 mg of nandrolone decanoate at the commencement of study and again one week later. Body weight, muscle (AMC), plasma transferrin, prealbumin, and retinol-binding protein were increased comparably in both groups. An apparent gain in total body nitrogen was not significant. However, anabolic steroid caused greater gain of water requiring a more liberal use of diuretics, but prevented the gains of fat, triglyceride and insulin that occurred in the control group. Most plasma amino acids increased due to intravenous hyperalimentation but decreased in patients given anabolic steroid. It is concluded that in patients who may be in the catabolic phase of recovery anabolic steroid probably enhances amino acid and water uptake by tissues and increases the utilization of fat but, does not promote any greater increase in "visceral" proteins than during intravenous hyperalimentation alone.

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Citations

Nov 1, 1987·Pflügers Archiv : European journal of physiology·S Egginton
Sep 1, 1990·The Journal of Steroid Biochemistry and Molecular Biology·C L MendenhallK Martin
Feb 24, 1998·Metabolism: Clinical and Experimental·M JeevanandamS R Petersen
Jul 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·A H Beddoe, G L Hill
Jul 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·D T HansellD C Carter
Jan 1, 1984·The British Journal of Surgery·G L Hill, J Church
Jul 1, 1987·Drug Intelligence & Clinical Pharmacy·J M Mirtallo, T Oh

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