Effects of an antenatal lifestyle intervention on offspring obesity - a 5-year follow-up of a randomized controlled trial

Acta Obstetricia Et Gynecologica Scandinavica
Ann-Kristin RonnbergKerstin Nilsson

Abstract

Strategies to limit excessive maternal gestational weight gain could also have positive health effects for the offspring. This study informs us on the effect of an antenatal lifestyle intervention on offspring body mass index (BMI) trajectory until age five. A secondary analysis of a randomized controlled trial aimed at reducing gestational weight gain, set in Ørebro, Sweden (Clinical Trials.gov Id NCT00451425). Offspring were followed with standardized measures of weight and height until age five. Mean BMI z-score and proportion (%) of over- and undernutrition (BMI z-score > ± 2 standard deviations) was compared between groups. Risk estimates for obesity at age five were analyzed in relation to maternal gestational weight gain and prepregnancy BMI as a secondary outcome. We analyzed 374 children at birth and 300 at age five. No significant difference in mean BMI z-score was seen at birth (0.68 (I) vs 0.56 (C), p = 0.242) or at age five (0.34 (I) vs 0.26 (C), p = 0.510) and no significant difference in proportion of over- or undernutrition was seen. Excessive maternal gestational weight gain was an independent risk factor for offspring obesity at birth (OR = 4.51, p < 0.001) but not at age five. Maternal obesity was an independ...Continue Reading

References

Mar 13, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·Lucilla Poston
Aug 24, 2013·Obstetrics and Gynecology·Margie H DavenportMichelle F Mottola
Oct 22, 2013·Archives of Gynecology and Obstetrics·Hong-Tao TieYong Zhao
Nov 5, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·Ak RonnbergK Nilsson
Mar 18, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P Catalano, S H deMouzon
Apr 29, 2015·Hormones and Behavior·Elinor L SullivanJeanette C Valleau
Jul 15, 2015·The Lancet. Diabetes & Endocrinology·Lucilla PostonUNKNOWN UPBEAT Trial Consortium
Feb 27, 2016·American Journal of Preventive Medicine·Jennifer A Woo BaidalElsie M Taveras
Apr 5, 2016·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Aakash PanditaAvinash Kaul
Apr 22, 2016·Acta Obstetricia Et Gynecologica Scandinavica·AnnKristin RonnbergKerstin Nilsson
May 18, 2016·Archives of Medical Science : AMS·Lidia A BiesiadaGrzegorz Krasomski

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Citations

Jul 3, 2018·Maternal & Child Nutrition·Kathryn V DalrympleMajella O'Keeffe
Apr 1, 2020·International Journal of Environmental Research and Public Health·Mercedes Díaz-RodríguezBernardo C Ferriz-Mas
Jan 9, 2021·The International Journal of Behavioral Nutrition and Physical Activity·Roxana RaabHans Hauner

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