PMID: 7541959Jun 1, 1995Paper

Effects of an endogenous inhibitor of nitric oxide synthesis on postcapillary venules

The American Journal of Physiology
I KuroseD N Granger

Abstract

The objective of this study was to determine whether an inhibitor of nitric oxide (NO) synthase (NG,NG'-dimethyl-L-arginine; L-DMA) that is produced by vascular endothelium elicits the inflammatory responses induced by synthetic analogues of L-arginine such as NG-nitro-L-arginine methyl ester (L-NAME). Leukocyte adherence and emigration, leukocyte-platelet aggregation, and albumin leakage were monitored in rat mesenteric venules exposed to different concentrations of either L-DMA or L-NAME. Increases in leukocyte adherence (7- to 9-fold) and emigration (3- to 5-fold), platelet-leukocyte aggregation, mast cell degranulation, and an enhanced albumin leakage (30-50%) were observed within 30 min after exposing the microvascular bed to either inhibitor; however, leukocyte emigration and albumin leakage responded more intensely to L-NAME than to L-DMA. The microvascular alterations and mast cell degranulation were attenuated by addition of L-arginine to the superfusate. These results suggest that the L-DMA is capable of eliciting an inflammatory response at concentrations detected in plasma under certain pathological conditions.

Citations

Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Sakuji ShigematsuRonald J Korthuis
Apr 3, 2004·American Journal of Respiratory and Critical Care Medicine·Habib M RazaviSanjay Mehta
Nov 30, 2000·American Journal of Physiology. Renal Physiology·M I ArcosR Zatz
Jan 26, 2011·Molecular and Cellular Biochemistry·Zhen-Yu PengMin Hu
Jun 17, 2020·Frontiers in Physiology·Pingnian HeFeng Gao
Jan 13, 2018·Journal of Cellular Physiology·Hamid MollazadehAmirhossein Sahebkar
Aug 12, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dan PredescuAsrar B Malik
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·R H Böger, S M Bode-Böger
Mar 3, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Dmitri Y Boudko

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