PMID: 3716519Apr 1, 1986

Effects of an enkephalin analog on motility of the small and large intestine in the cat

Zeitschrift für Gastroenterologie
M Wienbeck, M Blasberg


In order to study the effects of naturally occurring opioids on intestinal motility we exposed the unanesthetized cat to different doses of methionine (Met)-enkephalin analog DAMME. DAMME 10(-10) and 10(-9) M/kg body weight inhibited spike activity in the small intestine 20-50 min after injection, whereas in the colon doses as low as 10(-11) M/kg stimulated spiking. Transit of a radiopaque marker infused into duodenal and cecal catheters was delayed both in the small and large bowel. The enkephalin effect was inhibited by the opiate antagonist naloxone 10(-8) and 10(-7) M/kg in the colon, but only at 10(-7) M/kg in the small intestine. Atropine suppressed the enkephalin effect in the small, but not in the large bowel. DAMME caused central nervous side effects. It is concluded that the Met-enkephalin analog suppresses myoelectrical activity in the small intestine probably via cholinergic nervous pathways, and it stimulates spiking and segmenting contractions in the colon probably via a myogenic action. Opiate antagonists may be useful in the treatment of constipation if endogenous opioids are involved.

Related Concepts

Felis catus
Dose-Response Relationship, Drug
Surface Electromyography
FK 33-824
Intestinal Motility
Large Intestine
Intestines, Small
Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer

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