Effects of an ethanolic extract of mulberry fruit on blood pressure and vascular remodeling in spontaneous hypertensive rats

Clinical and Experimental Hypertension : CHE
Sang Woong ParkBok Hee Choi

Abstract

Mulberry (Morus alba) has been used in traditional oriental medicine since ages. Recently, it has been reported that mulberry produces hypotensive effects through the eNOS signaling pathway. However, the mechanism underlying the hypotensive effects of mulberry is not entirely clear. Moreover, the effects of mulberry on vascular remodeling events such as hyperplasia, an important etiology in the pathogenesis of hypertension and arteriosclerosis, are also ambiguous. Here, we hypothesized that an ethanolic extract of mulberry fruit (EMF) has beneficial effects on vascular remodeling and produces hypotensive effects. The effects of a 6-week oral administration of EMF were examined in spontaneously hypertensive rats (SHRs). The animals were divided into four groups: normotensive control (Wistar Kyoto rats), non-treated SHR, low-dose (100 mg/kg) EMF-treated SHR, and high-dose (300 mg/kg) EMF-treated SHR. Our results showed that the EMF-diet normalizes hypertension in SHRs in a dose-dependent manner, by preventing smooth muscle proliferation, thickening of the tunica media, and vascular hyper-reactivity. The endothelial functions were not substantially affected by the EMF diet in our experimental setting. In conclusion, we suggest tha...Continue Reading

References

Dec 1, 2006·International Journal of Food Sciences and Nutrition·Sarita SrivastavaRajesh Prakash Srivastava
Sep 15, 2010·Molecular Aspects of Medicine·Francisco Perez-Vizcaino, Juan Duarte
Apr 24, 2014·Pflügers Archiv : European journal of physiology·Sang Woong ParkHana Cho
Jan 17, 2015·Journal of Food Science and Technology·Akshatha ShrikantaVijayalakshmi Govindaswamy
Aug 8, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Alisson Macário de OliveiraThiago Henrique Napoleão
Mar 12, 2016·Bioscience, Biotechnology, and Biochemistry·Jiyun LeeYoung-Hee Lim
May 29, 2016·Molecular Nutrition & Food Research·Albino CarrizzoCarmine Vecchione
Sep 7, 2016·Journal of Ethnopharmacology·Alisson Macário de OliveiraThiago Henrique Napoleão
Nov 17, 2016·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Sang Woong ParkYoung Min Bae
Nov 14, 2017·Journal of Agricultural and Food Chemistry·Qingxia Yuan, Longyan Zhao

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