Abstract
Mulberry (Morus alba) has been used in traditional oriental medicine since ages. Recently, it has been reported that mulberry produces hypotensive effects through the eNOS signaling pathway. However, the mechanism underlying the hypotensive effects of mulberry is not entirely clear. Moreover, the effects of mulberry on vascular remodeling events such as hyperplasia, an important etiology in the pathogenesis of hypertension and arteriosclerosis, are also ambiguous. Here, we hypothesized that an ethanolic extract of mulberry fruit (EMF) has beneficial effects on vascular remodeling and produces hypotensive effects. The effects of a 6-week oral administration of EMF were examined in spontaneously hypertensive rats (SHRs). The animals were divided into four groups: normotensive control (Wistar Kyoto rats), non-treated SHR, low-dose (100 mg/kg) EMF-treated SHR, and high-dose (300 mg/kg) EMF-treated SHR. Our results showed that the EMF-diet normalizes hypertension in SHRs in a dose-dependent manner, by preventing smooth muscle proliferation, thickening of the tunica media, and vascular hyper-reactivity. The endothelial functions were not substantially affected by the EMF diet in our experimental setting. In conclusion, we suggest tha...Continue Reading
References
Feb 5, 2003·Cardiovascular Research·Alina PiechJean-Luc Balligand
Oct 19, 2005·Fitoterapia·Eun-Mi Choi, Jae-Kwan Hwang
Dec 1, 2006·International Journal of Food Sciences and Nutrition·Sarita SrivastavaRajesh Prakash Srivastava
Oct 25, 2008·Journal of Ethnopharmacology·Manli XiaQiang Xia
Sep 15, 2010·Molecular Aspects of Medicine·Francisco Perez-Vizcaino, Juan Duarte
Jun 19, 2013·Food Chemistry·Tao WuTing Yu
Sep 4, 2013·Experimental Biology and Medicine·Hyun Hwa LimYunsook Lim
Mar 13, 2014·Nutrition Research and Practice·Giuseppe ValacchiYunsook Lim
Apr 24, 2014·Pflügers Archiv : European journal of physiology·Sang Woong ParkHana Cho
Jan 17, 2015·Journal of Food Science and Technology·Akshatha ShrikantaVijayalakshmi Govindaswamy
Aug 8, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Alisson Macário de OliveiraThiago Henrique Napoleão
Mar 12, 2016·Bioscience, Biotechnology, and Biochemistry·Jiyun LeeYoung-Hee Lim
Apr 14, 2016·Biological Trace Element Research·Ewelina KrólRafał W Wójciak
May 29, 2016·Molecular Nutrition & Food Research·Albino CarrizzoCarmine Vecchione
Sep 7, 2016·Journal of Ethnopharmacology·Alisson Macário de OliveiraThiago Henrique Napoleão
Oct 7, 2016·Food & Function·Akshatha Hosahalli SrikantaVijayalakshmi Govindaswamy
Nov 17, 2016·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Sang Woong ParkYoung Min Bae
Feb 18, 2017·BMC Complementary and Alternative Medicine·Mesfin YimamQi Jia
Nov 14, 2017·Journal of Agricultural and Food Chemistry·Qingxia Yuan, Longyan Zhao
Jan 20, 2018·Pharmaceutical Biology·Thanchanit ThaipitakwongPornanong Aramwit
Citations
Jun 5, 2020·The Journal of Pharmacy and Pharmacology·Kamel ArrakiCorine Girard
Feb 13, 2021·Oxidative Medicine and Cellular Longevity·Dan-Dan ZhouHua-Bin Li
Apr 13, 2021·Frontiers in Physiology·Hua ChenHuijie Ma
May 23, 2021·International Journal of Biological Macromolecules·Mo LiJunrui Wu
Aug 28, 2021·Foods·Bo-Yoon ChangSung-Yeon Kim
Oct 15, 2021·Clinical and Experimental Hypertension : CHE·Anees Ahmed SyedJiaur R Gayen