Effects of an in-patient treatment program based on regular exercise and a balanced diet on high molecular weight adiponectin, resistin levels, and insulin resistance in adolescents with severe obesity

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Carine GueugnonGilles Dumoulin

Abstract

Adiponectin, the most abundant hormone produced by adipose tissue, circulates in 3 isoforms, including high molecular weight (HMW) adiponectin. The latter has been suggested to be a better predictor of metabolic disturbances and insulin resistance associated with obesity. This study investigated changes in total and HMW adiponectin, resistin, and homeostasis model assessment (HOMA) during a 9-month in-patient treatment program based on physical exercise and a balanced diet in 32 severely obese adolescents. Total and HMW adiponectin, resistin, and HOMA were measured at baseline (month 0) and during the program (months 3, 6, 9). In addition, a control group of 15 teenagers served as a reference for the baseline assessments. At baseline, HMW adiponectin was more markedly decreased in obese adolescents than total adiponectin, and both were lower than in controls. Conversely, resistin and HOMA were higher in obese adolescents. During the program, there was a significant change in body composition and improved insulin sensitivity among obese teenagers. In addition, HMW adiponectin and the ratio of HMW-to-total adiponectin increased throughout the study, whereas total adiponectin only increased up until the sixth month. On the contrar...Continue Reading

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Citations

Apr 7, 2015·The Journal of Nutritional Biochemistry·Maharshi BhaswantLindsay Brown
Mar 3, 2018·The Journal of Sports Medicine and Physical Fitness·Christian Cobbold
Feb 23, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Johanna RocheFabienne Mougin
Jan 9, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Johanna RocheDavid Thivel
Jun 7, 2020·The Journal of Pediatrics·Miguel Villasís-Keever, Jessie Zurita-Cruz

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