Effects of an inhibitor for calcium/calmodulin-dependent protein phosphatase, calcineurin, on induction of long-term potentiation in rat visual cortex

Neuroscience Research
M FunauchiT Tsumoto

Abstract

A role of Ca2+/calmodulin-dependent protein phosphatase (calcineurin) in induction of long-term potentiation (LTP) was investigated using its selective inhibitor, FK506, in visual cortical slices of young rats. Field potentials or excitatory postsynaptic potentials (EPSPs) to test stimulation of white matter were recorded extra- or intracellularly from layer 2/3, and tetanic stimulation (tetanus) was applied to the white matter at 5 Hz. During the application of FK506 (1 microM), short tetanus (6 s) which had rarely induced LTP in the normal medium, became effective in inducing LTP. Tetanus for 1 min in the presence of FK506 induced LTP with higher probability than in the normal medium. To test possible involvement of presynaptic mechanisms, paired pulses at 50 ms intervals were given to the white matter. The facilitation ratio of the second to first EPSPs was not significantly changed by FK506 and after the induction of LTP, suggesting that the action of FK506 may not be presynaptic. To confirm this, FK506 was injected directly into neurons through recording electrodes. In cases in which stable EPSPs were recorded, the probability of LTP induction became higher than that obtained with normal electrodes. These results suggest t...Continue Reading

References

Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C B KleeM H Krinks
May 1, 1992·Journal of Neurochemistry·T KunoC Tanaka
Aug 1, 1992·Progress in Neurobiology·T Tsumoto
Apr 1, 1992·Immunology Today·S L Schreiber, G R Crabtree
Jun 1, 1991·Current Opinion in Neurobiology·P Stemmer, C B Klee
May 20, 1991·Brain Research. Developmental Brain Research·N KatoW Singer
Jan 1, 1991·Annual Review of Neuroscience·D V MadisonR A Nicoll
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J Lisman
Jan 1, 1988·Journal of Neurophysiology·Y KomatsuK Toyama
Mar 1, 1973·The Journal of Physiology·R S Zucker
Jan 7, 1993·Nature·T V Bliss, G L Collingridge

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Citations

Feb 11, 1998·Molecular Neurobiology·B G Gold
Oct 1, 1994·Trends in Neurosciences·J Lisman
Jan 1, 1996·Journal of Physiology, Paris·Y Frégnac
Apr 4, 2003·Proceedings of the National Academy of Sciences of the United States of America·Shiv K SharmaThomas J Carew
Mar 22, 2002·The Journal of Biological Chemistry·Edwin J WeeberWilliam J Craigen
Apr 10, 2018·Neurobiology of Learning and Memory·Alejandro Rivera-OlveraMartha L Escobar
Jul 6, 2021·Frontiers in Cellular Neuroscience·Salma E Reyes-García, Martha L Escobar
Dec 19, 1998·Journal of Medicinal Chemistry·G S Hamilton, J P Steiner

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