Effects of an intensive behavioral weight loss intervention consisting of caloric restriction with or without physical activity on common carotid artery remodeling in severely obese adults.

Metabolism: Clinical and Experimental
Jennifer N CooperEmma Barinas-Mitchell

Abstract

Obesity increases cardiovascular disease risk and adversely affects vascular structure and function. Few studies have evaluated the vascular effects of non-surgical weight reduction in the severely obese. We hypothesized that weight loss and improvements in cardiometabolic factors would reduce common carotid artery intima-media thickness (CIMT) and inter-adventitial diameter (AD) in severely obese adults. We performed carotid ultrasound and measured cardiometabolic factors in 90 severely obese participants (body mass index (BMI)≥35 kg/m(2), age 30-55) at baseline and 6 months in a randomized clinical trial of dietary intervention with (n=45) or without (n=45) physical activity. The achieved weight loss (mean=8%) did not differ significantly by intervention group (P=0.10) and resulted in a 0.07 mm mean decrease in AD (P=0.001). AD change was positively correlated with changes in BMI, waist circumference, abdominal visceral and subcutaneous fat, and body fat mass, and AD decreased more in men (P<0.05 for all). After multivariable adjustment, changes in BMI (P=0.03) and abdominal subcutaneous fat (P=0.04) were significant determinants of AD change. Although CIMT did not decrease significantly overall (-0.008 mm, P=0.16), individua...Continue Reading

References

Jun 1, 1994·Circulation·W SteinkeM Hennerici
Sep 22, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K KarasonI Wendelhag
Dec 7, 2002·Stroke; a Journal of Cerebral Circulation·Mario De MichelePaolo Rubba
Oct 27, 2004·Diabetes·Cecilia C Low WangBoris Draznin
May 27, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S CzernichowM Zureik
Sep 9, 2005·Journal of Hypertension·Pantelis E ZebekakisJan A Staessen
Apr 4, 2006·Atherosclerosis·Jerzy Beltowski
Jul 3, 2008·The Journal of Clinical Endocrinology and Metabolism·Michaela KozakovaUNKNOWN Relationship between Insulin Sensitivity Cardiovascular risk Investigators
Jul 30, 2008·Archives of Internal Medicine·John M JakicicCarol Janney
Jan 14, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·G GuzzaloniA Liuzzi
Jun 9, 2009·European Heart Journal·Wolfgang SturmChristoph F Ebenbichler
Oct 21, 2009·The American Journal of Cardiology·Phillip HabibJ Ronald Mikolich
Jan 20, 2010·Journal of the American College of Cardiology·Lisa de las FuentesVictor G Davila-Roman
Oct 12, 2010·JAMA : the Journal of the American Medical Association·Bret H GoodpasterJohn M Jakicic
Dec 3, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Priscila de Lima SanchesAna Raimunda Dâmaso
Mar 16, 2011·Circulation·Paul PoirierUNKNOWN American Heart Association Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism
Jul 30, 2011·The American Journal of Medicine·Naser AhmadiRobert Siegel

❮ Previous
Next ❯

Citations

Nov 6, 2015·Current Diabetes Reports·J Robinson SingletonRobin L Marcus
Apr 10, 2014·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A BaillotM F Langlois
Jul 30, 2014·International Journal of Occupational and Environmental Health·Mark D WilsonSamuel Dorevitch
May 24, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·R J H M VerheggenD H T Thijssen
Jun 18, 2016·Nutrients·Concha F García-Prieto, María S Fernández-Alfonso
Dec 28, 2016·Obesity·Michael R SkiltonCrystal Man Ying Lee
May 1, 2013·Expert Review of Endocrinology & Metabolism·Sunil J Wimalawansa
May 20, 2020·Nutrients·Annelisa Silva E Alves de Carvalho SantosErika Aparecida Silveira
Jan 29, 2021·Critical Reviews in Food Science and Nutrition·Mousa KhalafiAmir Akbari
Apr 10, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Danielle L KirkmanDavid G Edwards
Jul 3, 2021·Journal of Personalized Medicine·Anna Maria RychterIwona Krela-Kaźmierczak
Nov 13, 2021·Critical Reviews in Food Science and Nutrition·Sara BeigrezaeiAmin Salehi-Abargouei

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.