Effects of an intervention to promote breastfeeding on maternal adiposity and blood pressure at 11.5 y postpartum: results from the Promotion of Breastfeeding Intervention Trial, a cluster-randomized controlled trial

The American Journal of Clinical Nutrition
Emily OkenRichard M Martin

Abstract

Differences between mothers who do and do not succeed in breastfeeding are likely to confound associations of lactation with later maternal adiposity. We compared adiposity and blood pressure (BP) in women randomly assigned to an intervention to promote prolonged and exclusive breastfeeding or usual care. We performed a cluster-randomized trial at 31 hospitals in Belarus in 1996-1997. Of 17,046 women enrolled at delivery, we assessed 11,867 women (69.6%) at 11.5 y postpartum. The prevalence of exclusive breastfeeding ≥3 mo was 44.5% in 6321 women in the intervention group and 7.1% in 5546 women in the control group. At 11.5 y postpartum, mean (±SD) body mass index (BMI; in kg/m(2)) was 26.5 ± 5.5, the percentage of body fat was 33.6% ± 8.3%, and systolic BP was 124.6 ± 14.6 mm Hg. On intention-to-treat analysis (without imputation) with adjustment for clustering by hospital, mean outcomes were lower in intervention compared with control mothers for BMI (mean difference: -0.27; 95% CI: -0.91, 0.37), body fat (-0.49%; 95% CI: -1.25%, 0.27%), and systolic BP (-0.81 mm Hg; 95% CI: -3.33, 1.71 mm Hg), but effect sizes were small, CIs were wide, and results were attenuated further toward the null after adjustment for baseline charact...Continue Reading

References

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Citations

Jul 25, 2015·Cancer Epidemiology·Annie S AndersonIsabelle Romieu
Mar 8, 2016·American Journal of Obstetrics and Gynecology·Malamo E CountourisJanet M Catov
May 7, 2015·American Journal of Epidemiology·Julie R PalmerLynn Rosenberg
May 7, 2015·American Journal of Epidemiology·Eleanor Bimla Schwarz
Jun 15, 2016·International Journal of Epidemiology·M S KramerRobert W Platt
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Nov 21, 2019·The Cochrane Database of Systematic Reviews·Elisha RiggsJudith C Gomersall
Aug 5, 2015·Obstetrics and Gynecology·Erica P GundersonCora E Lewis
Oct 13, 2015·Clinical Obstetrics and Gynecology·Alison Stuebe
May 12, 2020·Journal of the American Heart Association·Alexis C WoodAmerican Heart Association Council on Lifestyle and Cardiometabolic Health; Council on Epidemiology and Prevention; Council
Sep 13, 2019·Scientific Reports·Natália Peixoto LimaBernardo L Horta
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Jun 6, 2018·JAMA Internal Medicine·Erica P Gunderson, Cora E Lewis
Jun 6, 2018·JAMA Internal Medicine·Veronica Velle-ForbordEszter Vanky
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Related Concepts

Diastolic Blood Pressure
Breast Feeding, Exclusive
Health Campaigns
Lactation, Prolonged
Maternal Welfare
Body Mass Index Procedure
Adiposity
Blood Pressure
Breast Feeding
Clinical Trials

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