Effects of an intervention to promote breastfeeding on maternal adiposity and blood pressure at 11.5 y postpartum: results from the Promotion of Breastfeeding Intervention Trial, a cluster-randomized controlled trial

The American Journal of Clinical Nutrition
Emily OkenRichard M Martin


Differences between mothers who do and do not succeed in breastfeeding are likely to confound associations of lactation with later maternal adiposity. We compared adiposity and blood pressure (BP) in women randomly assigned to an intervention to promote prolonged and exclusive breastfeeding or usual care. We performed a cluster-randomized trial at 31 hospitals in Belarus in 1996-1997. Of 17,046 women enrolled at delivery, we assessed 11,867 women (69.6%) at 11.5 y postpartum. The prevalence of exclusive breastfeeding ≥3 mo was 44.5% in 6321 women in the intervention group and 7.1% in 5546 women in the control group. At 11.5 y postpartum, mean (±SD) body mass index (BMI; in kg/m(2)) was 26.5 ± 5.5, the percentage of body fat was 33.6% ± 8.3%, and systolic BP was 124.6 ± 14.6 mm Hg. On intention-to-treat analysis (without imputation) with adjustment for clustering by hospital, mean outcomes were lower in intervention compared with control mothers for BMI (mean difference: -0.27; 95% CI: -0.91, 0.37), body fat (-0.49%; 95% CI: -1.25%, 0.27%), and systolic BP (-0.81 mm Hg; 95% CI: -3.33, 1.71 mm Hg), but effect sizes were small, CIs were wide, and results were attenuated further toward the null after adjustment for baseline charact...Continue Reading


Mar 10, 2001·JAMA : the Journal of the American Medical Association·M S KramerPROBIT Study Group (Promotion of Breastfeeding Intervention Trial)
Jun 25, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·R SichieriW C Willett
Feb 3, 2005·Pediatrics·Lawrence M GartnerAmerican Academy of Pediatrics Section on Breastfeeding
Jul 5, 2005·Journal of Psychosomatic Research·Elizabeth Sibolboro MezzacappaEdward S Katkin
Sep 27, 2005·Journal of the American Dietetic Association·Julie D RitchieHelen Smiciklas-Wright
Aug 17, 2006·Journal of Women's Health·Adi CohenLori A Bastian
Mar 3, 2007·Obstetrics and Gynecology·Erica P GundersonSteve Sidney
Nov 26, 2008·American Journal of Perinatology·Alison Stuebe, Janet W Rich-Edwards
Dec 10, 2008·The American Journal of Clinical Nutrition·Jennifer L BakerKathleen M Rasmussen
Jan 1, 2009·The American Journal of Clinical Nutrition·Katherine M FlegalNathaniel Schenker
Apr 23, 2009·Obstetrics and Gynecology·Eleanor Bimla SchwarzJane A Cauley
Jun 13, 2009·Obesity·Jihong LiuJames E Ferguson
Aug 25, 2009·BMJ : British Medical Journal·M S KramerRobert W Platt
Oct 16, 2009·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Stanley IpJoseph Lau
Dec 23, 2009·Obstetrics and Gynecology·Eleanor Bimla SchwarzKim C Sutton-Tyrrell
May 13, 2010·Journal of Women's Health·Alison StuebeJanet W Rich-Edwards
Aug 31, 2010·The American Journal of Medicine·Eleanor Bimla SchwarzDavid Thom
Feb 23, 2011·Maternal & Child Nutrition·Adelheid W OnyangoWHO Multicentre Growth Reference Study Group
Mar 16, 2011·Maternal and Child Health Journal·Candace K McClureEleanor Bimla Schwarz
Jul 2, 2011·Obesity·Candace K McClureKim C Sutton-Tyrrell
Oct 15, 2011·American Journal of Epidemiology·Alison StuebeJohn Forman
Mar 15, 2012·BMC Medical Research Methodology·Lauren GuthrieRichard M Martin
Jul 11, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K L BobrowMillion Women Study Collaborators
Mar 14, 2013·JAMA : the Journal of the American Medical Association·Richard M MartinEmily Oken


Jul 25, 2015·Cancer Epidemiology·Annie S AndersonIsabelle Romieu
Mar 8, 2016·American Journal of Obstetrics and Gynecology·Malamo E CountourisJanet M Catov
May 7, 2015·American Journal of Epidemiology·Julie R PalmerLynn Rosenberg
May 7, 2015·American Journal of Epidemiology·Eleanor Bimla Schwarz
Jun 15, 2016·International Journal of Epidemiology·M S KramerRobert W Platt
May 6, 2016·Annual Review of Nutrition·Cria G PerrineKelley S Scanlon
May 29, 2015·The American Journal of Clinical Nutrition·Andrew W BrownDavid B Allison
Nov 10, 2018·Journal of Developmental Origins of Health and Disease·Romy GaillardVincent W V Jaddoe
Nov 22, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·Veronica Velle-ForbordEszter Vanky
Mar 1, 2017·The Cochrane Database of Systematic Reviews·Alison McFaddenStephen MacGillivray
Nov 21, 2019·The Cochrane Database of Systematic Reviews·Elisha RiggsJudith C Gomersall
Aug 5, 2015·Obstetrics and Gynecology·Erica P GundersonCora E Lewis
Oct 13, 2015·Clinical Obstetrics and Gynecology·Alison Stuebe
May 12, 2020·Journal of the American Heart Association·Alexis C WoodAmerican Heart Association Council on Lifestyle and Cardiometabolic Health; Council on Epidemiology and Prevention; Council
Sep 13, 2019·Scientific Reports·Natália Peixoto LimaBernardo L Horta
Feb 21, 2019·Cadernos de saúde pública·Natália Peixoto LimaBernardo L Horta
Jun 6, 2018·JAMA Internal Medicine·Erica P Gunderson, Cora E Lewis
Jun 6, 2018·JAMA Internal Medicine·Veronica Velle-ForbordEszter Vanky
Nov 1, 2017·Obesity·Emily OkenLeanne M Redman
Oct 10, 2018·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Eliana BonifacinoJennifer A Corbelli

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Diastolic Blood Pressure
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