Abstract
A novel intra-ventricular assist device (iVAD) was established as a new pulsatile assist device to address various disadvantages, such as bulky configuration and reduced arterial pulsatility, observed in conventional ventricular assist devices. Analyzed the native left ventricular stroke volume (SV) after iVAD support in vitro. The SV of iVAD was examined in a home-designed mock circulatory system (MCS) at different heart rates and drive pressures and the SV of a failure ventricle was examined with iVAD at 75, 90, 120 bpm and 120-180 mmHg drive pressure after iVAD support. Data pertaining to native left ventricular SV before and after iVAD support were compared. The native ventricular SV was improved by iVAD when its drive pressure (DP) was slightly greater than that of the mock system. Conversely, the native ventricular SV was decreased when DP was much greater than that (150 mmHg) of MCS. A high DP had a significant effect on SV. The proposed device improved the dysfunctional native left ventricular SV when DP of iVAD was slightly greater than that of MCS. However, iVAD reduced the SV when the drive pressure was greater than that of MCS.
References
Nov 1, 1991·Cardiovascular Research·C T BowlesM H Yacoub
Jun 11, 2008·Medical & Biological Engineering & Computing·Nico WesterhofBerend E Westerhof
Jul 6, 2011·Artificial Organs·Gianfranco FerrariMaciej Kozarski
Jul 28, 2012·The Annals of Thoracic Surgery·Michael P O'NeilLinrui Ray Guo
May 8, 2013·Artificial Organs·Ashraf William Khir, Gianpaolo Bruti
Mar 13, 2014·Journal of Biomechanics·K WongK May-Newman
Apr 9, 2014·Biomedical Engineering Online·Seong Wook ChoiSung Min Park
Jul 30, 2014·Medical Engineering & Physics·Selim BozkurtMarcel C M Rutten
Oct 29, 2014·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Markus FerrariKyriakos Spiliopoulos
Feb 6, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Arudo HiraokaY Joseph Woo
Apr 14, 2015·Artificial Organs·Shigang WangAkif Ündar
Nov 3, 2015·Expert Review of Cardiovascular Therapy·Erin M SchumerMark S Slaughter
Nov 1, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Mohamed ZeriouhAron-Frederik Popov
Jun 30, 2016·Expert Review of Medical Devices·Johannes WappenschmidtAndreas Goetzenich
Jul 29, 2016·Annals of Biomedical Engineering·Johannes WappenschmidtAndreas Goetzenich