PMID: 589932Nov 1, 1977

Effects of analgesics and related compounds on renal metabolism in rats

Clinical Science and Molecular Medicine
J D TangeJ G Ledingham

Abstract

1. The metabolic effects of p-aminophenol have been compared with those of paracetamol and other analgesics in studies of rat liver and kidney in vitro. 2. p-Aminophenol injected into rats inhibited gluconeogenesis from lactate in renal cortical tubules, but not in isolated hepatocytes, and reduced kidney ATP content without affecting the ATP content of liver. Perfused kidneys from rats previously injected with p-aminophenol showed a 50% reduction of ATP content, severe inhibition of Na+ reabsorption and reduction of inulin clearance without significant inhibition of gluconeogenesis from lactate. 3. Paracetamol, p-phenetidine, phenazone and aspirin, when given intravenously to rats, had no effect on renal tubular glucose synthesis from lactate or pyruvate. Paracetamol and aspirin both slightly inhibited renal glucose synthesis from several different substrates when added directly to tubules. 4. Paracetamol (4 mmol/l) inhibited glucose synthesis from lactate and other substrates by 50% or more in isolated hepatocytes. Glucose synthesis from lactate was inhibited 30% by concentrations of paracetamol as low as 0.5 mmol/l. 5. These results indicate that p-aminophenol is a potent inhibitor of proximal tubular function, with its main...Continue Reading

Citations

Jun 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R EyanagiH Shigematsu
Jan 1, 1989·Archives of Toxicology·K P GartlandJ K Nicholson
Aug 15, 1979·Gastrointestinal Radiology·M J Homer, J M Braver
Feb 15, 2001·Journal of Biochemical and Molecular Toxicology·H Song, T S Chen

Related Concepts

Adenosine Triphosphate, Chromium Ammonium Salt
Antinociceptive Agents
Aniline Compounds
Zorprin
Gluconeogenesis
Kidney
Liver
Phenols

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