Effects of androgen manipulation on alpha1-adrenoceptor subtypes in the rat seminal vesicle

Life Sciences
Fúlvio R MendesMaria C W Avellar

Abstract

This study analyses possible changes during surgical and chemical castration in the expression and pharmacological characteristics of alpha1-adrenoceptor in adult rat seminal vesicle. Ribonuclease protection assays indicated that alpha1a--was the predominant mRNA, while alpha1b-and alpha1d-adrenoceptor transcripts were detected in lower abundance in this tissue. alpha1a-adrenoceptor mRNA expression presented a complex dependency on androgens, while alpha1b- and alpha1d-adrenoceptor transcripts were both upregulated with surgical and chemical castration, suggesting a negative modulation by androgens. Testosterone treatment reversed the effects caused by surgical castration. Functional studies confirmed the involvement of alpha1A- and alpha1B-adrenoceptor in the seminal vesicle contractile responses, and suggested that alpha1B-induced contractile response was upregulated after castration. Taken together, the results suggest that alpha1-adrenoceptor expression in seminal vesicle is differentially regulated by the androgen status of the rat.

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Citations

Mar 21, 2008·Cell and Tissue Research·Daniel Barboza Cava QueirózMaria Christina W Avellar
Jun 25, 2010·Molecular and Cellular Endocrinology·Erick J R SilvaMaria Christina W Avellar
Feb 17, 2006·Molecular and Cellular Endocrinology·Margarete HamamuraCatarina S Porto
Sep 2, 2009·Anais Da Academia Brasileira De Ciências·Maria Christina W AvellarCatarina S Porto
Feb 12, 2020·Molecular and Cellular Endocrinology·Noemia A P MarianiErick J R Silva
Jan 15, 2019·Archives of Biochemistry and Biophysics·Priscila de O CoelhoMarcelo D Gomes

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