Aug 1, 1997

Effects of anesthetic technique on side effects associated with fentanyl Oralet premedication

Journal of Clinical Anesthesia
S MalviyaW Green


To evaluate the efficacy of 5 to 10 micrograms/kg of oral transmucosal fentanyl citrate (OTFC) as an anesthetic premedication, and to determine whether propofol induction reduces postoperative nausea and vomiting (PONV) in pediatric patients premedicated with OTFC undergoing outpatient surgery. Prospective, randomized, double-blinded study. University of Michigan Health Care Systems and University of Arizona. 62 ASA physical status I and II children aged 4 to 14 years (8.9 +/- 0.5 years). Subjects were randomly assigned to one of four groups: (1) OTFC premedication and halothane induction; (2) OTFC premedication and propofol induction; (3) placebo premedication and halothane induction; and (4) placebo premedication and propofol induction. OTFC or placebo was administered 30 minutes prior to induction, and activity (sedation), apprehension, and cooperation scores were recorded before, at 15 and 30 minutes after study drug, and on induction. All perioperative adverse events were recorded. Children who received OTFC became drowsier and had a significant change from baseline in combined activity, apprehension, and cooperation scores, whereas those who received placebo became less cooperative at induction. Patients who received OTFC...Continue Reading

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Mentioned in this Paper

Anesthetics, Intravenous
Buccal Mucosa
Double-Blind Method

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