Effects of angiographic contrast media on sino-atrial nodal function

Cardiovascular Research
C W WhiteF M Abboud

Abstract

Injection of meglumine diatrizoate (Renografin-76) into the selectively perfused sinus node artery of the dog produces bradycardia which is unaltered by autonomic blockade or by changes in sinus node artery pressure. Contrast agents and other hyperosmolar substances prolong the R-R interval in proportion to their osmolarity. Selective injection of contrast media into other cannulated segments of the coronary tree produces no change in heart rate. Transfemoral arteriography, however, produces bradycardia with both right and left coronary injections. Both direct and reflex sinus node depression occur with coronary arteriography in the dog. Direct effects are mediated by hyperosmolarity.

Citations

Jan 1, 1982·Cardiovascular and Interventional Radiology·A Weikl, M Hubmann
Oct 1, 1984·British Heart Journal·R Hayward, P Dawson
Oct 26, 1990·The American Journal of Cardiology·J A Brinker
May 1, 1986·Progress in Cardiovascular Diseases·P C HanleyH C Smith
Sep 5, 1989·The American Journal of Cardiology·P Dawson
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Aug 1, 1996·Journal of Cardiovascular Electrophysiology·K G Lurie, D Benditt
Mar 10, 1999·The American Journal of Physiology·K G LurieS Motomura

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