Effects of angiotensin-converting enzyme inhibition on angiotensin and bradykinin peptides in rats with myocardial infarction

Journal of Cardiovascular Pharmacology
A M DuncanD J Campbell

Abstract

Angiotensin-converting enzyme (ACE) inhibitors reduce myocardial remodeling and improve cardiac function after myocardial infarction. We investigated whether the beneficial effects of ACE inhibition were associated with changes in the levels of angiotensin and bradykinin peptides in blood, heart, lung, aorta, and kidney. Rats subjected to coronary artery ligation and selected by ECG criteria to have moderate to large myocardial infarctions (mean size, 38%) were administered perindopril (0, 20, 200, and 2,000 micrograms/kg/day) in their drinking water from the second day after surgery for 26 days. Perindopril caused a dose-related decrease in blood pressure and inhibited the development of both cardiac hypertrophy (estimated by heart weight/body weight ratio) and cardiac failure (estimated by lung weight/body weight ratio). Perindopril inhibited plasma ACE activity and increased plasma renin, with an associated decrease in plasma angiotensinogen. Plasma and all tissues showed a marked reduction in angiotensin II/angiotensin I ratio, indicating effective inhibition of ACE in plasma and tissues. Whereas heart, lung, and kidney showed dose-related decreases in angiotensin II (Ang II) levels, plasma and aortic levels of Ang II were ...Continue Reading

References

Apr 1, 1992·British Journal of Pharmacology·W Linz, B A Schölkens
Aug 1, 1991·The New England Journal of Medicine·UNKNOWN SOLVD InvestigatorsJay N Cohn
Apr 1, 1990·Clinical and Experimental Pharmacology & Physiology·B FabrisC I Johnston
Sep 1, 1989·Circulation·H DrexlerT Bonzel
Aug 1, 1988·Circulation·G P HodsmanC I Johnston
Jul 1, 1985·Circulation Research·J M PfefferE Braunwald
Aug 1, 1995·Circulation Research·T YamazakiK Tobe
Jun 1, 1993·Journal of Cardiovascular Pharmacology·J C HartmanR J Shebuski
May 1, 1995·Hypertension·D J CampbellS L Skinner
Jan 1, 1995·The Journal of Clinical Investigation·Y NioM Inada
Oct 24, 1994·European Journal of Pharmacology·K HelinF Fyhrquist
Sep 1, 1994·Cardiovascular Research·Y SunK T Weber
Jun 1, 1993·Circulation·W G Guntheroth
Nov 1, 1993·Journal of Molecular and Cellular Cardiology·H YamagishiT Takeda
Oct 1, 1993·Hypertension·D J CampbellA M Duncan
Feb 1, 1993·Hypertension·D J CampbellA M Duncan

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Citations

Jul 9, 2011·Clinical and Experimental Pharmacology & Physiology·Duncan J CampbellGordon K Smyth
Apr 28, 2004·Trends in Endocrinology and Metabolism : TEM·Louise M BurrellMark E Cooper
Jan 30, 2015·Journal of Human Hypertension·J WangY Wang
Apr 2, 2003·Expert Opinion on Therapeutic Targets·John Howl, Sarah J Payne
Apr 18, 2008·European Journal of Pharmacology·Dilek IusufAnton J M Roks
Apr 14, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·E VelkoskaM J Morris
Jan 27, 2005·European Heart Journal·Louise M BurrellColin I Johnston
Jun 1, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D J Campbell
May 20, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Rachael G DeanLouise M Burrell
May 19, 2010·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Sinda MahjoubSaida Ben Arab
Mar 1, 2001·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Trefor Morgan
Mar 8, 2003·Hypertension·Duncan John Campbell
Dec 17, 2008·Hypertension·Hisko OeseburgAnton J M Roks
Mar 12, 2015·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Sarah SharpEdward D Sturrock
Aug 5, 1998·The American Journal of Physiology·L M BurrellC I Johnston

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