PMID: 9547443Apr 21, 1998Paper

Effects of angiotensin-converting enzyme inhibitor on plasma B-type natriuretic peptide levels in patients with acute myocardial infarction

Journal of Cardiac Failure
Y MizunoK Nakao

Abstract

Plasma levels of B-type natriuretic peptide (BNP) are markedly increased in patients with heart failure and acute myocardial infarction. The changes in plasma BNP levels in the treatment of acute myocardial infarction with angiotensin-converting enzyme inhibitors have not been examined well. This study was designed to examine the effects of early angiotensin-converting enzyme inhibitor therapy on plasma BNP levels in patients with acute myocardial infarction. We measured the plasma levels of B-type natriuretic peptide over the time course for 2 weeks in 30 patients with acute myocardial infarction in whom either imidapril (n = 15) or placebo (n = 15) was given at random immediately after admission. Plasma BNP levels increased and reached a peak of 192 +/- 28 pg/ML 16 hours after administration; thereafter, the levels decreased and then again increased, forming the second peak of 217 +/- 38 pg/ML on the fifth day (biphasic pattern). On the other hand, plasma BNP levels increased and reached a peak level of 190 +/- 22 pg/ML 16 hours after admission and then decreased from 2 days after admission until the second week in the imidapril group (monophasic pattern). Left ventricular ejection fraction measured in the second week was sig...Continue Reading

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Citations

May 15, 2002·International Journal of Cardiology·Tomohiro SakamotoHirofumi Yasue
Dec 19, 1998·Journal of the American College of Cardiology·D J van VeldhuisenH J Crijns
Aug 28, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·J MairB Puschendorf
Jun 16, 2011·Canadian Journal of Physiology and Pharmacology·Yoshihiko SaitoKazuwa Nakao
Oct 5, 2010·Journal of cardiology·Yoshihiko Saito
Feb 23, 2005·Expert Review of Cardiovascular Therapy·Cara A WasywichRobert N Doughty
Aug 15, 2002·Cardiovascular Drug Reviews·Kazuyoshi Hosoya, Toshihiko Ishimitsu

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