PMID: 11724639Nov 29, 2001Paper

Effects of angiotensin II (AT1) receptor blockade on cardiac vagal control in heart failure

Clinical Science
J C VaileJ N Townend

Abstract

The objective of the present study was to determine the autonomic effects of angiotensin II (AT(1)) receptor blocker therapy in heart failure. In a randomized double-blind cross-over study, we compared the effects of candesartan and placebo on baroreflex sensitivity and on heart rate variability at rest, during stress and during 24 h monitoring. Acute effects were assessed 4 h after oral candesartan (8 mg) and chronic effects after 4 weeks of treatment (dose titrated to 16 mg daily). The study group comprised 21 patients with heart failure [mean (S.E.M.) ejection fraction 33% (1%)], in the absence of angiotensin-converting enzyme (ACE) inhibitor therapy. We found that acute candesartan was not different from placebo in its effects on blood pressure or mean RR interval. Chronic candesartan significantly reduced blood pressure [placebo, 137 (3)/82 (3) mmHg; candesartan, 121 (4)/75 (2) mmHg; P<0.001; values are mean (S.E.M.)], but had no effect on mean RR interval [placebo, 857 (25) ms; candesartan, 857 (21) ms]. Compared with placebo there were no significant effects of acute or chronic candesartan on heart rate variability in the time domain and no consistent effects in the frequency domain. Baroreflex sensitivity assessed by th...Continue Reading

Citations

Feb 11, 2004·Progress in Biophysics and Molecular Biology·Irving H ZuckerKaushik P Patel
Nov 5, 2003·American Heart Journal·Elisabetta De TommasiMaria Vittoria Pitzalis
Feb 12, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rohit RamchandraClive N May
Dec 20, 2008·Journal of Applied Physiology·Gaelle DeleyJ Andrew Taylor
Oct 7, 2010·Heart Failure Reviews·Monali Y DesaiPaul J Hauptman
Jan 9, 2014·Psychophysiology·Chia-Ying ChouChris R Brewin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Related Papers

The Journal of Nervous and Mental Disease
K A Dubester, B G Braun
International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology
Raúl LópezJavier Moltó
Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD)
Karni GinzburgDavid Spiegel
© 2021 Meta ULC. All rights reserved