PMID: 8945996Nov 1, 1996Paper

Effects of angiotensin II on cultured rat renomedullary interstitial cells are mediated by AT1A receptors

The American Journal of Physiology
Christine MaricDaine Alcorn

Abstract

Renomedullary interstitial cells (RMICs) are prominent in the inner medullary interstitium and have binding sites for several vasoactive agents, including angiotensin II (ANG II). Although the functional role of RMICs remains largely unknown, it is likely that the interaction between RMICs and vasoactive peptides is important in the regulation of renal function. The current investigation characterizes the cellular responses following treatment of RMICs with ANG II. Studies were performed on RMICs isolated from Sprague-Dawley rat kidneys. 125I-labeled [Sar1,Ile8]ANG II specifically bound to RMICs at sites determined by reverse transcription-polymerase chain reaction to be of the AT1A subtype. ANG II (10(-6) and 10(-10) M) had no effect on either basal or forskolin-stimulated adenosine 3',5'-cyclic monophosphate accumulation in RMICs but increased intracellular inositol 1,4,5-trisphosphate concentration after 10 s and intracellular calcium concentration after 18 s. For RMICs plated at low densities, ANG II (10(-6) M) induced an increase in [3H]thymidine incorporation, mediated through the AT1-receptor subtype. For RMICs plated at high densities, ANG II (10(-6) M) induced an increase in extracellular matrix synthesis as detected b...Continue Reading

Citations

Jan 17, 2003·American Journal of Physiology. Renal Physiology·Thomas L PalloneKristie Rhinehart
Sep 23, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jennifer L RogersSusan E Mulroney
Aug 16, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sunghou LeeChristine Maric
Dec 18, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kai ChenJames C Rose
Jul 9, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Inge CarlsenRikke Nørregaard
Nov 15, 2013·American Journal of Physiology. Renal Physiology·Martin OstergaardRikke Nørregaard
Dec 14, 2017·International Journal of Molecular Sciences·Sara StridhPeter Hansell
Sep 1, 1996·Clinical and Experimental Pharmacology & Physiology·D AlcornC Maric

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