Effects of angiotensin II on the blood flow and its distribution in fetal lambs

Circulation Research
H S Iwamoto, A M Rudolph

Abstract

We studied the effects of intravenous infusion of angiotensin II on the circulation of the fetus in lambs in utero through chronically maintained intravascular catheters. Angiotensin II infused in doses of 29-280 ng/min per kg fetal weight resulted in an increase in plasma angiotensin II from a control value of 87 +/- 17 to 341 +/- 129 (mean +/- SE) pg/ml; these levels are similar to those observed following hemorrhage in fetal lambs. Fetal mean arterial blood pressure increased from 46 +/- 2.0 to 56 +/- 2.7 torr and fetal heart rate increased from 172 +/- 6 to 189 +/- 6 beats/min, an effect which was not altered by beta-adrenergic or cholinergic blockade. Fetal cardiac output and its distribution were measured before and during infusion of angiotensin II by the radionuclide-labeled microsphere technique. Combined ventricular output increased significantly from 526 +/- 32 to 616 +/- 24 ml/min per kg fetal body weight. Angiotensin constricted the umbilical-placental circulation as well as the gastrointestinal, renal, and thyroidal vascular beds. Angiotensin increased blood flow to the myocardium and markedly increased blood flow to the pulmonary circulation. These studies indicate that angiotensin II, at the plasma levels achiev...Continue Reading

References

Apr 1, 1977·Physiological Reviews·M J Peach
Jan 1, 1979·Biology of the Neonate·E R Lumbers, J L Lewes
Nov 1, 1979·American Journal of Obstetrics and Gynecology·T N Tulenko
Feb 1, 1978·The Australian Journal of Experimental Biology and Medical Science·E R Lumbers, G C Reid
Jan 1, 1978·Biology of the Neonate·W BermanA M Rudolph
Mar 1, 1977·The Journal of Surgical Research·E L KaplanB J Hill
Jul 1, 1977·Progress in Cardiovascular Diseases·M A HeymannA M Rudolph
Jul 1, 1967·The American Journal of Physiology·J A KrasneyR F Lowe
Feb 1, 1971·The American Journal of Physiology·P J DempseyT Cooper
Jun 11, 1973·The American Journal of Physiology·P NeedlemanG R Marshall
Jun 1, 1974·Pediatric Research·F G SmithR A Bashore
Sep 1, 1974·The Journal of Physiology·F Broughton PipkinJ C Mott
Dec 1, 1974·The Journal of Physiology·F Broughton PipkinJ C Mott
Dec 1, 1972·Pediatric Research·E A LebowitzA M Rudolph
Apr 1, 1972·Journal of Applied Physiology·K KitamuraY Wang
Oct 1, 1971·Journal of Applied Physiology·G D BuckbergD E Fixler
Mar 15, 1962·American Journal of Obstetrics and Gynecology·N S ASSALIN SEHGAL

❮ Previous
Next ❯

Citations

May 25, 2010·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Dane A CrossleyKent L Thornburg
Jan 31, 1992·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H van HuisselingT H Hasaart
Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·N M Buckley
Mar 24, 1999·Pediatric Research·B E Cox, C R Rosenfeld
Jun 1, 2001·Pediatric Research·J L SegarF S Lamb
Nov 24, 2004·Pediatric Research·Blair E CoxCharles R Rosenfeld
Nov 1, 1988·American Journal of Obstetrics and Gynecology·J A Low
Jan 1, 1986·American Journal of Obstetrics and Gynecology·A J PeralesC R Rosenfeld
Dec 1, 1991·American Journal of Obstetrics and Gynecology·M G RossR D Leake
Nov 1, 1991·American Journal of Obstetrics and Gynecology·O W JonesR A Brace
Nov 1, 1989·American Journal of Obstetrics and Gynecology·A R Hohimer, J M Bissonnette
May 1, 1993·American Journal of Obstetrics and Gynecology·C R RosenfeldP W Shaul
Nov 1, 1989·Baillière's Clinical Endocrinology and Metabolism·E BirkM A Heymann
Sep 8, 2009·Clinics in Perinatology·Adré J du Plessis
Jan 1, 1992·Ultrasound in Medicine & Biology·S L Adamson, B L Langille
Jun 1, 1994·Early Human Development·J W Wladimiroff
Apr 1, 1993·Journal of Pediatric Surgery·J F SabikF L Hanley
Feb 1, 1989·Alcoholism, Clinical and Experimental Research·R T Savoy-MooreR J Sokol
Jun 1, 1983·Circulation Research·R A Brace
Sep 6, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Casey A MuellerDane A Crossley
Apr 6, 2019·Current Pharmaceutical Design·Emilie HitzerdA H Jan Danser
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Mitsuaki ItoShigehiko Mizutani
Jan 26, 2002·British Medical Bulletin·D J Barker
Apr 8, 1998·The American Journal of Physiology·J R KaiserC R Rosenfeld
Nov 11, 1985·The American Journal of Physiology·S S CrandellF H Morriss
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K MoritzE M Wintour
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·R RobinsonC A Gleason
Oct 1, 1985·The American Journal of Physiology·B M WilkesP F Mento
Sep 1, 1992·The American Journal of Physiology·C R RosenfeldR R Magness
Jun 1, 1996·Baillière's Clinical Obstetrics and Gynaecology·J A Low

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.