Effects of angiotensin, vasopressin and atrial natriuretic peptide on intraocular pressure in anesthetized rats

Neuropeptides
D E PalmW B Severs

Abstract

The effects of atrial natriuretic peptide (ANP), vasopressin (AVP) and angiotensin (ANG) on blood and intraocular pressures of pentobarbital anesthetized rats were evaluated following intravenous, intracerebroventricular or anterior chamber routes of administration. Central injections did not affect intraocular pressure. Equipressor intravenous infusions of ANG raised, whereas AVP decreased, intraocular pressure. Direct infusions of a balanced salt solution (0.175 microliter/min) raised intraocular pressure between 30 and 60 min. Adding ANG or ANP slightly reduced this solvent effect but AVP was markedly inhibitory. An AVP-V1 receptor antagonist reversed the blunting of the solvent-induced rise by the peptide, indicating receptor specificity. Acetazolamide pretreatment lowered intraocular pressure, but the solvent-induced rise in intraocular pressure and inhibition by AVP still occurred without altering the temporal pattern. Thus, these effects appear unrelated to aqueous humor synthesis rate. The data support the possibility of intraocular pressure regulation by peptides acting from the blood and aqueous humor.

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Citations

Jun 29, 2000·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·F LacheretzG Le Fur
Nov 30, 2013·Pharmacology & Therapeutics·Michael J Giese, Robert C Speth
Dec 17, 2011·Experimental Eye Research·Rong-Fang WangOvidiu C Baltatu
Feb 17, 1998·Experimental Eye Research·C D BalabanW B Severs
Sep 23, 1997·Biochemical and Biophysical Research Communications·R V PatilM B Wax
Dec 9, 2017·Current Medical Research and Opinion·Janusz SkrzypeckiMarcin Ufnal

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