Effects of anidulafungin and voriconazole, singly and in combination, on cytokine/chemokine production by human monocyte-derived macrophages infected with Candida glabrata or activated by lipopolysaccharide

Chemotherapy
Aldona L BaltchRaymond P Smith

Abstract

Candida glabrata causes infections associated with severe sepsis, production of high concentrations of cytokines/chemokines, and high mortality. This study describes the effects of anidulafungin (ANF) and voriconazole (VRC), singly and in combination, on the production of eight cytokines/chemokines by human monocyte-derived macrophages (MDM) infected with C. glabrata or activated by lipopolysaccharide (LPS). MDM monolayers were established, infected with C. glabrata or activated with LPS, and then treated with high or low concentrations of ANF, VRC, or both. Cytokine/chemokine levels in MDM supernatants were determined. Levels of cytokines/chemokines were significantly elevated in supernatants of infected or LPS-activated MDM. Except for interleukin-10, all significant decreases in cytokine/chemokine concentrations (p < 0.01) occurred in supernatants of infected MDM treated with high concentrations of ANF or ANF + VRC. Decreases in cytokine/chemokine levels in supernatants of infected MDM treated with high concentrations of ANF or ANF + VRC suggest that similar treatment could improve survival in patients with severe, invasive C. glabrata infections and markedly elevated levels of serum cytokines/chemokines.

References

Jun 24, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L J Rodriguez-AdrianE J Anaissie
Dec 20, 2000·Antimicrobial Agents and Chemotherapy·A L BaltchL H Bopp
Mar 29, 2001·Medical Mycology·T R Traynor, G B Huffnagle
Aug 31, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Casadevall, L A Pirofski
Oct 2, 2002·Journal of Clinical Microbiology·M A Pfaller, D J Diekema
Sep 23, 2003·Immunity·Gordon D Brown, Siamon Gordon
Nov 11, 2003·Trends in Microbiology·Ulrike K Rapp, Stefan H E Kaufmann
Nov 26, 2003·Antimicrobial Agents and Chemotherapy·Jung-Hyun ChoiWan-Shik Shin
Jan 20, 2004·Trends in Cell Biology·D Thomas Rutkowski, Randal J Kaufman
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hilmar WisplinghoffMichael B Edmond
Mar 12, 2005·Cellular Microbiology·Gordon D Brown, Siamon Gordon
Sep 28, 2006·Translational Research : the Journal of Laboratory and Clinical Medicine·Keiichi KinoshitaTakanori Ueda
Oct 13, 2006·Current Opinion in Infectious Diseases·M T Labro
Jul 31, 2007·Future Microbiology·Jose A Vazquez
May 27, 2008·The Journal of Infectious Diseases·David A Stevens
Jun 11, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R Ben-AmiD P Kontoyiannis
Aug 8, 2008·Blood·David C DaleW Conrad Liles
Apr 16, 2009·Clinical Microbiology Reviews·Trine H Mogensen
May 16, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David L HornKaren M Webster

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Citations

Jun 13, 2020·Frontiers in Cellular and Infection Microbiology·Louise A Walker, Carol A Munro

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