Effects of anodized implants coated with Escherichia coli-derived rhBMP-2 in beagle dogs

International Journal of Oral and Maxillofacial Surgery
Jung-Bo HuhSang-Wan Shin

Abstract

This study evaluated the effects of Escherichia coli-derived rhBMP-2 (ErhBMP-2) coated onto anodized implants to stimulate bone formation, osseointegration and vertical bone growth in a vertical bone defect model. Six young adult beagle dogs were used. After a 2-month bone healing period, anodized titanium implants (8mm in length) were placed 5.5mm into the mandibular alveolar ridge. Eighteen implants coated with ErhBMP-2 (BMP group) and another 18 uncoated implants (control group) were installed using a randomized split-mouth design. The implant stability quotient (ISQ) values were measured. Specimens were fabricated for histometric analysis to evaluate osseointegration and bone formation. The ISQ values at 8 weeks after implant placement were significantly higher in the BMP group than in the control group (p<0.05). Histological observations showed that the changes in bucco-lingual alveolar bone levels were higher in the BMP group than in the control group (p<0.05). The ErhBMP-2 coated anodized implants can stimulate bone formation and increase implant stability significantly on completely healed alveolar ridges in dogs. Further studies evaluating the effects of ErhBMP-2 on osseointegration in the bone-implant interface are wa...Continue Reading

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Citations

Oct 1, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Jin-Yong LeeJong-Ho Lee
Jun 16, 2016·Journal of Biomedical Materials Research. Part a·Gregor JennyBernd Stadlinger
Jan 29, 2019·The Journal of Craniofacial Surgery·Ali H Abbas Alhussaini
May 12, 2016·Advanced Materials·Małgorzata A WronskaJ Gerard Wall
Apr 7, 2017·Tissue Engineering and Regenerative Medicine·Graziella BelloneGiorgio Emanuelli
Jun 9, 2017·Head & Face Medicine·Lara SchornRita Depprich
Jul 14, 2019·The Journal of Craniofacial Surgery·Ali H Abbas Alhussaini
Jun 3, 2021·Materials·Saturnino Marco LupiSilvana Rizzo

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