Effects of anorexigenic peptide on gastric and pancreatic secretion

The Journal of Physiology
D CoyJ Tasler

Abstract

1. Gastric and pancreatic secretion as well as serum gastrin an insulin levels have been measured after sham-feeding, real feeding or exogenous hormonal stimulation in conscious dogs receiving (pyro) Glu-His-Gly, an appetite depressing peptide (AP). 2. Sham-feeding produced a marked increase in gastric acid and pepsin outputs accompanied by an elevation of serum gastrin and insulin concentrations. AP infusion before and after sham-feeding reduced the peak gastric secretion and suppressed gastrin and insulin responses to sham-feeding. 3. Liver extract meal administered into the stomach resulted in an increase in gastric acid and serum gastrin and insulin levels. AP inhibited acid response to liver extract without affecting serum hormonal levels. Pentagastrin stimulation produced similar acid secretion to that obtained with liver extract and AP infusion also inhibited this secretion. 4. Secretin infusion or feeding a meat meal produced a similar rate of pancreatic bicarbonate secretion in dogs with chronic pancreatic fistula. AP infusion inhibited the bicarbonate response to feeding or secretin without affecting serum gastrin or insulin levels. 5. This study demonstrates that pyro-Glo-His-Gly suppresses serum hormonal and gastric...Continue Reading

Citations

Sep 1, 1990·International Journal of Peptide and Protein Research·A V SchallyR Z Cai
Jan 27, 1999·Biochimica Et Biophysica Acta·P M Cummins, B O'Connor
Nov 1, 1986·Biological Psychiatry·K L ReicheltJ B Bøler

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