Effects of anterior cingulate cortex lesions on ocular saccades in humans

Experimental Brain Research
B GaymardC Pierrot-Deseilligny

Abstract

Cerebral blood flow studies in humans suggest that the anterior cingulate cortex (ACC) could be involved in eye movement control. In two patients with a small infarction affecting the posterior part of this area (on the right side) and in ten control subjects, we studied several paradigms of saccadic eye movements: gap task, overlap task, antisaccades (using either a 5 degrees or 25 degrees lateral target), memory-guided saccades with a short (1 s) or long (7 s) delay, and sequences of memory-guided saccades. Compared with controls, patients had normal latency in the gap task but increased latency in the other tasks. The gain of memory-guided saccades was markedly decreased, bilaterally, whatever the duration of the delay. Patients made more errors than controls in the antisaccade task when the 5 degrees lateral target was used, and a higher percentage of chronological errors in the sequences of saccades. These results show that the posterior part of the right ACC plays an important role in eye movement control and suggest that this area could correspond to a "cingulate eye field" (CEF). The role of this hypothetical CEF could be an early activation exerted on the frontal ocular motor areas involved in intentional saccades and ...Continue Reading

Citations

Jul 3, 2013·Psychopharmacology·Ksenija MarinkovicAdrian K C Lee
May 26, 2005·Experimental Brain Research·A TzelepiZ Kapoula
May 6, 2011·Experimental Brain Research·Annelies GeritsWim Vanduffel
Aug 29, 2012·Journal of Neural Transmission·S YerramI Bodis-Wollner
Mar 5, 2013·Behavioural Brain Research·Aldis P Weible
Jul 17, 2001·Biological Psychology·J E McDowell, B A Clementz
Mar 31, 2010·Journal of Cognitive Neuroscience·Jessica M PhillipsStefan Everling
Mar 6, 2013·PloS One·Lakshminarayan SrinivasanEmad N Eskandar
Jun 24, 2014·Journal of Ophthalmology·Martin GorgesJan Kassubek
Feb 3, 2016·Frontiers in Systems Neuroscience·Theresa M DesrochersDavid L Sheinberg
Sep 5, 2001·The Journal of Physiology·P JohannsenJ B Nielsen
Jul 12, 2002·Annals of Neurology·Charles Pierrot-DeseillignyChristoph J Ploner
Mar 17, 2010·Neuropsychologia·Uraina S ClarkAlice Cronin-Golomb
Aug 12, 2009·Progress in Neurobiology·Céline Amiez, Michael Petrides
May 26, 2009·Journal of the American Academy of Child and Adolescent Psychiatry·E Mark MahoneMartha B Denckla
Sep 25, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Koen P GrootensRobbert J Verkes
Nov 17, 2006·Brain and Cognition·Adrian G LaskerDavid S Zee
Jul 13, 2005·Psychophysiology·Ulrich EttingerPhilip J Corr
Apr 14, 2005·Annals of the New York Academy of Sciences·Dan MileaAlain Berthoz
Apr 14, 2005·Annals of the New York Academy of Sciences·Ch Pierrot-DeseillignyD Milea
Jun 30, 2006·Psychophysiology·Samuel B Hutton, Ulrich Ettinger
Nov 26, 2010·The European Journal of Neuroscience·Brendan B Chapman, Brian D Corneil
May 4, 2005·Biological Psychiatry·Christoph J PlonerCharles Pierrot-Deseilligny
Aug 18, 2004·Biological Psychology·Ulrich EttingerPhilip J Corr
Apr 5, 2003·Current Biology : CB·Matthias Niemeier, Hans Otto Karnath
Feb 15, 2005·Vision Research·Linda A Tkalcevic, Larry A Abel
May 24, 2016·Neuroscience and Biobehavioral Reviews·Edna C CieslikSimon B Eickhoff
Jul 6, 2016·Journal of Cognitive Neuroscience·Kelly ShenJennifer D Ryan
Sep 28, 2016·Nature Neuroscience·Amitai ShenhavMatthew M Botvinick
Jun 1, 2012·Psychiatry Research·Jennifer MalsertChristian Marendaz
Jun 26, 2003·Journal of Child Neurology·Adrian G LaskerDavid S Zee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.