Abstract
Our goal was to examine the effect of anti-inflammatory agents on the migration of lymphocytes to cutaneous inflammatory sites and in response to cytokines. The accumulation of i.v. injected 111In-labelled peritoneal exudate lymphocytes in skin sites of rats injected with KLH to induce DTH reactions, LPS, poly I:C and the cytokines, IFN-gamma, IFN-alpha/beta and tumor necrosis factor was determined. Systemic dexamethasone (DEX) treatment strongly inhibited the migration of lymphocytes in response to all of the stimuli, however, the effective dose of DEX varied widely with the different recruiting agents. The lowest ED50 was observed with LPS, while IFN-alpha/beta was the least inhibited. DEX treatment increased lymphocyte accumulation in the bone marrow and spleen. Pretreatment of lymphocytes with DEX had no effect on their migration, while local i.d. hydrocortisone inhibited migration into the skin. Cyclosporin A treatment had no effect on lymphocyte recruitment in response to any of the cytokines or LPS but significantly inhibited migration to DTH reactions and poly I:C. Treatment of rats with indomethacin, ASA and BW755C produced only a marginal inhibition of lymphocyte migration in response to some of the stimuli tested. DE...Continue Reading
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