Effects of anti-inflammatory agents on lymphocyte migration stimulated by the interferons, tumor necrosis factor and cutaneous inflammation.

International Journal of Immunopharmacology
T B Issekutz

Abstract

Our goal was to examine the effect of anti-inflammatory agents on the migration of lymphocytes to cutaneous inflammatory sites and in response to cytokines. The accumulation of i.v. injected 111In-labelled peritoneal exudate lymphocytes in skin sites of rats injected with KLH to induce DTH reactions, LPS, poly I:C and the cytokines, IFN-gamma, IFN-alpha/beta and tumor necrosis factor was determined. Systemic dexamethasone (DEX) treatment strongly inhibited the migration of lymphocytes in response to all of the stimuli, however, the effective dose of DEX varied widely with the different recruiting agents. The lowest ED50 was observed with LPS, while IFN-alpha/beta was the least inhibited. DEX treatment increased lymphocyte accumulation in the bone marrow and spleen. Pretreatment of lymphocytes with DEX had no effect on their migration, while local i.d. hydrocortisone inhibited migration into the skin. Cyclosporin A treatment had no effect on lymphocyte recruitment in response to any of the cytokines or LPS but significantly inhibited migration to DTH reactions and poly I:C. Treatment of rats with indomethacin, ASA and BW755C produced only a marginal inhibition of lymphocyte migration in response to some of the stimuli tested. DE...Continue Reading

References

Jun 15, 1979·Biochemical Pharmacology·G A HiggsJ R Vane
May 1, 1986·Cellular Immunology·T B IssekutzD M Webster
Apr 15, 1989·Cellular Immunology·T B Issekutz, J M Stoltz
Dec 1, 1974·The Journal of Clinical Investigation·J J RinehartA F LoBuglio
Oct 15, 1984·The American Journal of Medicine·J S Goodwin
Apr 1, 1983·The Australian Journal of Experimental Biology and Medical Science·A W Thomson

❮ Previous
Next ❯

Citations

Jul 12, 2001·Nutrition Research·H KwakR R. Dietert
Nov 1, 1995·Parasitology·A L Neill, N H Hunt
Apr 28, 2001·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·P Kulkarni
Jan 1, 1994·Journal of Ocular Pharmacology·P S Kulkarni
Jan 10, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Robert Sackstein
Sep 25, 2009·Beilstein Journal of Organic Chemistry·Jean-Christophe Andrez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here