Effects of anti-TNF therapy on glucose metabolism in patients with ankylosing spondylitis, psoriatic arthritis or juvenile idiopathic arthritis

Biologicals : Journal of the International Association of Biological Standardization
Bárbara Santos Pires da SilvaJozélio Freire de Carvalho

Abstract

The objective of this study was to evaluate the influence of anti-tumor necrosis factor (anti-TNF) in juvenile idiopathic arthritis (JIA), ankylosing spondylitis (AS) or psoriatic arthritis (PsA). Sixty-two patients were investigated: 7 JIA; 37 AS; and 18 PsA. Caucasian race accounted for 79% and 29% were female. Mean age was 40.4 +/- 12.6 years. None of the patients had a history of diabetes, and none had used oral hypoglycemic agents or insulin. Treatment was with adalimumab, infliximab and etanercept. Glucose, inflammatory markers and prednisone dose were assessed at baseline, as well as after three and six months of treatment. The mean erythrocyte sedimentation rate was significantly lower at three months and six months than at baseline (13.7 +/- 18.0 and 18 +/- 22.5 vs. 27.9 +/- 23.4 mm; p = 0.001). At baseline, three months and six months, we found the following: mean C-reactive protein levels were comparable (22.1 +/- 22.7, 14.5 +/- 30.7 and 16.0 +/- 23.8 mg/L, respectively; p = 0.26); mean glucose levels remained unchanged (90.8 +/- 22.2 mg/dl, 89.5 +/- 14.6 mg/dl and 89.8 +/- 13.6 mg/dl, respectively; p = 0.91); and mean prednisone doses were low and stable (3.9 +/- 4.9 mg/day, 3.7 +/- 4.8 mg/day and 2.6 +/- 4.0 mg/day...Continue Reading

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Citations

Jan 12, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Verena WieserHerbert Tilg
Nov 13, 2015·Expert Review of Clinical Immunology·Francesco CasoLuisa Costa
Jun 9, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Jiayun ShenLai-Shan Tam
Nov 27, 2015·Seminars in Arthritis and Rheumatism·Fabrizio CantiniUNKNOWN Italian board for the TAilored BIOlogic therapy (ITABIO)
Jan 9, 2019·Arthritis & Rheumatology·Yulin YuanTianfu Wu
Mar 10, 2020·Expert Review of Clinical Immunology·Francesco CasoLuisa Costa
Apr 20, 2020·Rheumatology and Therapy·Giacomo Dal BelloGiampiero Girolomoni
Jul 25, 2019·Pediatric Rheumatology Online Journal·Emmanuelle RochetteEtienne Merlin
May 24, 2019·Frontiers in Physiology·Emmanuelle RochettePascale Duché
Feb 7, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·A NastC Dressler
Nov 20, 2021·Rheumatology and Therapy·Sneha Patel, Anand Kumthekar

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