PMID: 7941677Jan 1, 1994Paper

Effects of antianginal therapy with atenolol and slow-release nifedipine on respiratory gas exchange and on the ventilatory requirements for aerobic exercise

Zeitschrift für Kardiologie
M HetzelV Hombach

Abstract

The effects of atenolol and nifedipine on gas exchange were studied in 27 patients with effort angina in a randomized cross-over trial. Semi-supine bicycle exercise tests (ramp program, 20 W/min) with measurement of gas exchange were carried out after consecutive 2-week treatment periods with atenolol (50 mg b.i.d.) and slow-release nifedipine (20 mg b.i.d.). In the range of subthreshold exercise, the slope of the VO2 workload line was lower with atenolol than with nifedipine (8.64 +/- 1.59 vs 10.28 +/- 1.74 ml.min-1.W-1, p < 0.005) as determined by linear regression analysis excluding the initial 30 W. The intercept of the curve on the VO2 axis was higher with atenolol than with nifedipine (366 +/- 111 vs 299 +/- 113 ml.min-1, p < 0.05). VO2 was higher (p < 0.05) with nifedipine than with atenolol for workloads above 65 W. A similar pattern was seen if the drug effects on the slope of the VCO2-workload relation were analyzed (7.11 +/- 1.92 vs 8.54 +/- 1.85 ml.min-1.W-1, p < 0.02). The intercept on the VCO2 axis was not different among the treatments. VCO2 was higher (p < 0.05) with nifedipine than with atenolol for workloads above 55 W. Minute ventilation was higher (p < 0.05) with nifedipine than with atenolol at all points o...Continue Reading

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