PMID: 2485901Nov 1, 1989Paper

Effects of antiarrhythmic drugs in the isolated papillary muscle preparation of the guinea-pig

Polish Journal of Pharmacology and Pharmacy
J Bandolet, S Rump

Abstract

Antiarrhythmic effects of a series of N-substituted derivatives of 2-amino-2-methylpropanol were studied using isolated papillary muscle preparation of guinea-pig heart in order to evaluate the chemical structure--biological activity relationship. All tested drugs were found to belong to the 1st group of antiarrhythmic agents characterized by the depression of normal electrophysiological properties of the heart muscle cell. The most active compounds were phenylethyl and p-bromophenylethyl derivatives, the effects of which were comparable with those of quinidine.

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Cardiac Electrophysiology

Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.