Effects of antiarrhythmic drugs on atrioventricular conduction in patients with acute myocardial infarction

Circulation
M M ScheinmanJ A Abbott

Abstract

Three hundred fifty-eight of 429 (83%) consecutive patients with acute myocardial infarction (MI) and a normal PR interval received various antiarrhythmic drugs (AD), including lidocaine and/or procainamide, quinidine, digoxin, propranolol or disopyramide. There was no significant difference in the incidence of progression to any degree of atrioventricular (AV) block or to higher degrees of AV block (Mobitz II or third-degree AV block) between those treated and not treated with AD: 38 of 358 (11%) and six of 358 (1.7%) with AD vs 11 of 71 (15%) and two of 71 (2.8%) in the untreated group, respectively. Similarly, there was no significant difference in progression between treated and untreated patients with anterior MI, 14 of 144 (10%) vs five of 32 (16%); inferior MI, 21 of 111 (19%) vs five of 26 (19%), or subendocardial MI, three of 103 (3%) vs one of 12 (8%). Bundle branch block (BBB) (without AV block) was initially present in 89 of 249 (21%). The incidence of AV block (seven of 24, 30%) was higher in treated patients with newly acquired BBB (27 patients) than in the untreated patients (none of three, p less than 0.05). The commonly used ADs did not adversely affect AV conduction in patients with acute MI with narrow QRS an...Continue Reading

References

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Citations

Aug 1, 1990·Pharmacology, Biochemistry, and Behavior·D L Jones, S Lo

Related Concepts

Cardiac Depressants
Anterior Fascicular Block
Mapluxin
Disopyramide, L-Tartrate, (S)-isomer
Heart Block
Cardiac Conduction System
Lidocaine Monohydrochloride, Monohydrate
Myocardial Infarction
Rhythmin
Rexigen

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