Effects of antibiotic treatment on the results of nested PCRs for scrub typhus.

Journal of Clinical Microbiology
Dong-Min Kim, Joo Nam Byun

Abstract

In order to determine the effects of antibiotic treatment on the results of nested PCRs for scrub typhus, we investigated the frequency of positive outcomes at various times after antibiotic administration in patients with scrub typhus. The rate of detection by nested PCR with blood buffy coat before antibiotic administration was 90.5%. However, this decreased to 60.5% within 3 days after administration of antibiotics such as doxycycline and rifampin and to 10% by the fourth day following antibiotic administration. Since the sensitivity of nested PCR can be affected by antibiotic administration, clinicians should perform this PCR before antibiotic administration and at the latest within 3 days after antibiotic administration.

References

Apr 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Buddha BasnyatDavid R Murdoch
Oct 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dong-Min KimSeung-Hyun Lee
Jan 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stuart D BlacksellNicholas P J Day
Dec 7, 2007·Infectious Disease Clinics of North America·Elisabeth Botelho-Nevers, Didier Raoult

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Citations

Nov 12, 2010·Journal of Clinical Microbiology·Dong-Min KimJohn Stenos
Nov 4, 2011·The American Journal of Tropical Medicine and Hygiene·Jun LeeMi Ah Han
Sep 2, 2016·Japanese Journal of Infectious Diseases·Nitin GuptaVishnubhatla Sreenivas
Mar 11, 2017·PLoS Neglected Tropical Diseases·Nicole L MendellDavid H Walker
Dec 22, 2010·Tropical Doctor·Senaka RajapakseSumadhya Deepika Fernando
Mar 2, 2012·Journal of Korean Medical Science·Moon-Hyun ChungJae-Seung Kang
Mar 28, 2019·The American Journal of Tropical Medicine and Hygiene·Hang Jin JeongDong-Min Kim
Mar 13, 2019·The American Journal of Tropical Medicine and Hygiene·Meghna PhanichkrivalkosilStuart D Blacksell

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