PMID: 9553647Apr 29, 1998Paper

Effects of antibodies to transferrin and alpha 2-HS glycoprotein on in vitro sperm motion: implications in infertility associated with endometriosis

American Journal of Reproductive Immunology : AJRI
S PillaiL Howard

Abstract

Women with endometriosis have antibodies to endometrial transferrin and alpha 2-HS glycoprotein in their serum and peritoneal fluid. The objective of this study was to determine whether antibodies to transferrin and alpha 2-HS glycoprotein adversely affect sperm motility and survival. Spermatozoa obtained from normal fertile donors and washed free of seminal plasma were incubated with the medium (control), 1:2 and 1:100 dilutions of antitransferrin, 1:4, 1:8 and 1:100 dilutions of anti-alpha 2-HS glycoprotein, and a 1:2 dilution of antialbumin antiserum (negative control). Sperm motion characteristics in 10 microliters aliquots were evaluated at 30 min, 1 hr, 2 hr, 4 hr, and 24 hr using computerized sperm motion analysis. A paired t-test was done to analyze the effects of the various antibodies on sperm motion characteristics. Antibodies to albumin failed to adversely affect sperm motility in general or the several sperm motion characteristics in particular. In contrast, antibodies to transferrin at the dilution of 1:2 adversely affected the percentage of motile and rapid spermatozoa, progressive and path velocities, straightness, linearity, track speed, and anterior-lateral head displacement (P < 0.001) at all the time interva...Continue Reading

References

Sep 30, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·A BouttenG Durand
Sep 1, 1991·American Journal of Reproductive Immunology : AJRI·H MoriT Tamaya
Nov 1, 1991·Fertility and Sterility·M KoutsilierisA Lemay
Aug 1, 1991·Fertility and Sterility·G A DunselmanJ L Evers
Feb 1, 1990·Fertility and Sterility·E ConfinoN Gleicher
Jan 1, 1990·Archives of Andrology·X ShuxiangS Mathur
Feb 1, 1987·American Journal of Reproductive Immunology and Microbiology : AJRIM·R A WildA C Shivers
Jun 1, 1988·American Journal of Reproductive Immunology and Microbiology : AJRIM·S MathurH O Williamson
Jan 1, 1987·American Journal of Obstetrics and Gynecology·D BartosikJ A Riley
Jan 1, 1987·Archives of Gynecology·P BöszeJ László
Nov 1, 1986·American Journal of Reproductive Immunology and Microbiology : AJRIM·S MathurH O Williamson
Jul 1, 1985·American Journal of Reproductive Immunology and Microbiology : AJRIM·R A Wild, C A Shivers
Jan 1, 1986·Fertility and Sterility·D A MetzgerR R Franklin
Jan 1, 1983·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·A SaifuddinH Fox
Nov 1, 1982·Clinical and Experimental Immunology·S MathurH H Fudenberg
Sep 1, 1980·Clinical Obstetrics and Gynecology·B Ranney
Aug 1, 1982·International Journal of Radiation Oncology, Biology, Physics·E M Röttinger, M Mendonca
Sep 1, 1994·Zhonghua yi xue za zhi = Chinese medical journal; Free China ed·C R TzengA C Chen
Nov 1, 1993·Fertility and Sterility·P BielfeldL J Zaneveld
Feb 1, 1993·British Journal of Obstetrics and Gynaecology·P CurtisR W Shaw
May 1, 1996·American Journal of Reproductive Immunology : AJRI·S PillaiH Zhang

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Citations

Jun 14, 2002·Journal of Reproductive Immunology·Neal G Mahutte, Aydin Arici
Feb 3, 2007·Journal de gynécologie, obstétrique et biologie de la reproduction·J-L PoulyL Janny
Jun 5, 2012·Journal of Proteomics·Carlos Eduardo A SouzaArlindo A Moura
Apr 23, 2013·Theriogenology·M F van TilburgA A Moura
Aug 15, 2018·International Journal of Molecular Sciences·Yi-Heng LinYen-Hua Huang
Oct 14, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Simone FerreroJurgis G Grudzinskas

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