Effects of anticholinesterase drugs on biomarkers and behavior of pumpkinseed, Lepomis gibbosus (Linnaeus, 1758)

Journal of Environmental Monitoring : JEM
Sara RodriguesB Nunes

Abstract

The presence of pharmaceutical residues in the aquatic environment has recently received great attention, as potential adverse effects may arise from their presence. Inhibition of cholinesterases (ChE) has been widely used as an environmental biomarker of exposure to organophosphates (OP) and carbamate (CB) pesticides. However, other widespread anthropogenic contaminants - including pharmaceutical drugs - can exert toxic effects through ChE inhibition. Studies with aquatic species have shown that inhibition of ChE is associated with behavioral changes. Bearing this in mind, this work aimed to study the effects on individual behavior and acetylcholinesterase (AChE) activity of selected tissues of Lepomis gibbosus, after exposure to the anticholinesterasic drugs neostigmine and pyridostigmine. Results revealed that neostigmine significantly decreased the activity of AChE in the head (LOEC = 100 mg L(-1)), but not in dorsal muscle. On the other hand, pyridostigmine significantly decreased the activity of AChE in both the head (LOEC = 0.001 mg L(-1)) and dorsal muscle homogenates (LOEC = 100 mg L(-1)). The impairment of this enzymatic form was attained at ecologically relevant concentrations (in the case of pyridostigmine, for head...Continue Reading

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Citations

Jun 4, 2014·Environmental Science and Pollution Research International·Bruno NunesSara C Antunes
Feb 12, 2013·Environmental Science and Pollution Research International·Flávio Henrique Tincani OsórioCiro Alberto de Oliveira Ribeiro
Nov 19, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tomas BrodinMicael Jonsson
Aug 11, 2018·Environmental Science and Pollution Research International·Gregorio Nolazco MatusBruno Nunes

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