Aug 1, 1975

Effects of antidepressant drugs on amygdaloid after-discharge in rats

Japanese Journal of Pharmacology
C KameiM Shimizu

Abstract

Effects of antidepressant drugs on the amygdaloid after-discharge induced by stimulating the amygdala in rats implanted with chronic electrodes, were investigated in correlation with anti-muricidal effects as well as neurotoxicity. Tricyclic antidepressants such as amitriptyline, imipramine and nortriptyline markedly depressed both after-discharge and muricide at doses smaller than neurotoxic doses. The effect of PF-257 was also the same as tricyclic antidepressants. On the other hand, methamphetamine and pipradrol blocked the muricide at doses smaller than neurotoxic doses without depressing the amygdaloid after-discharge. Major tranquilizers, chlorpromazine and clozapine depressed both after-discharge and muricide only at doses larger than those which impaired rotarod performance. Haloperidol, on the contrary, depressed the after-discharge without selectively blocking the muricide. Minor tranquilizers, diazepam and chlordiazepoxide did not block the muricide at doses smaller than neurotoxic doses, although they showed a marked depression of the after-discharge.

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Mentioned in this Paper

Antipsychotic Effect
Behavior, Animal
Anti-Anxiety Effect
Amitriptyline Hydrochloride
Madrine
Thymoleptics
Thorazine
Amygdaloid Structure
Valium
Tricyclic Antidepressive Agents

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