PMID: 12766643May 27, 2003Paper

Effects of antidepressants on function and viability of human neutrophils

Anesthesiology
Danja StrümperMarco A E Marcus

Abstract

Antidepressants are frequently used in chronic pain therapy and are under investigation as long-acting local anesthetics. Because of the structural similarities between antidepressants and local anesthetics, the authors hypothesized that these compounds act similarly, and they investigated the effects of nortriptyline, amitriptyline, imipramine, and fluoxetine on priming and activation of human polymorphonuclear neutrophils (hPMNs). Effects of 30-, 120-, and 240-min preincubation with nortriptyline (10(-7)-10(-4) M), amitriptyline (10(-6)-10(-3) M), imipramine (10(-6)-10(-3) M), or fluoxetine (10(-7)-10(-4) M) on O(2)- generation of platelet activating factor-primed (10-6 M) and/or formyl-methionyl-leucyl-phenylalanine-activated (10(-6) M) isolated hPMNs were determined. All data are reported as mean +/- SD (statistics: t test, P < 0.05). Brief incubation in low concentrations of nortriptyline, amitriptyline, or fluoxetine (all at 10(-5) M) did inhibit priming but not activation of hPMNs. Imipramine (10(-5) M) affected neither priming nor activation. Prolonged incubation in lower concentrations of all antidepressants influenced neither priming nor activation. However, at higher concentrations, all four compounds exerted cytotox...Continue Reading

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Citations

Sep 23, 2008·Anesthesia and Analgesia·Annette PloppaMarcel E Durieux
Nov 6, 2007·Toxicology·A M Moreno-FernándezP Navas
May 22, 2007·The Journal of Pain : Official Journal of the American Pain Society·Peter FridrichPeter Gerner
Sep 28, 2004·Basic & Clinical Pharmacology & Toxicology·Shu-Shong HsuChung-Ren Jan
Jun 1, 2011·Basic & Clinical Pharmacology & Toxicology·Silvia NovíoManuel Freire-Garabal
Mar 15, 2005·Anesthesiology Clinics of North America·J Lee White, Marcel E Durieux
Feb 2, 2013·Life Sciences·Luciana Romina Frick, Maximiliano Rapanelli
Oct 27, 2007·Regional Anesthesia and Pain Medicine·Bohdan PomahacPeter Gerner
Sep 9, 2006·Current Opinion in Anaesthesiology·Danja Strumper Groves
May 13, 2004·Regional Anesthesia and Pain Medicine·Danja Strumper, Marcel E Durieux
Nov 14, 2018·Scientific Reports·Harvey G RowethGavin E Jarvis
Mar 24, 2021·Neurochemical Research·Noura Magdy ThabetEnas Mahmoud Moustafa

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