Effects of antiepileptic drug on thyroid hormones in patients with epilepsy: A meta-analysis

Seizure : the Journal of the British Epilepsy Association
Yin-Xi ZhangMei-Ping Ding

Abstract

As antiepileptic drugs (AEDs) are known to be associated with alterations in thyroid profiles, we aimed to carry out a meta-analysis to comprehensively assess the effects of AEDs on thyroid hormones in patients with epilepsy. We searched the NCBI (PubMed), ISI Web of Science, EMBASE databases, and Cochrane Library to identify studies evaluating the association between AED use and thyroid hormone profiles in patients with epilepsy. Fixed or random effects meta-analysis was used to pool results across studies. In all, 35 studies were included in our analysis. Out of a total of 997 patients in these studies, epileptic patients receiving AEDs showed an overall significant decrease in thyroxin (T4) and free T4 (fT4) and higher levels of thyroid stimulating hormone (TSH) than the controls (T4: standardized mean difference [SMD]=-1.839, 95% confidence interval [CI], -2.063 to -1.614; fT4: SMD=-1.190, 95% CI, -1.687 to -0.692; TSH: SMD=0.445, 95% CI, 0.031-0.858). Notably, the use of carbamazepine (CBZ) suggested a significant decrease in triiodothyronine (T3), T4, and fT4; phenytoin (PHT) use showed a decrease in T4 and fT4; and valproic acid (VPA) use was associated with decreased T4 and increased TSH. Our study suggests that use of ...Continue Reading

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Citations

Apr 2, 2017·Seizure : the Journal of the British Epilepsy Association·Fu-Yuan ShihMeng-Han Tsai
Jan 12, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Engin KoseNur Arslan
Jul 7, 2018·Therapeutic Advances in Endocrinology and Metabolism·Grzegorz M RdzakSilvio E Inzucchi

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