Effects of Antiepileptic Drug Tapering on Episodic Memory as Measured by Virtual Reality Tests

Frontiers in Neurology
Yvonne HöllerEugen Trinka

Abstract

Antiepileptic drugs impair episodic memory in patients with epilepsy, but this effect has so far only been examined with tests that do not provide first-person experience-an aspect that is crucial for episodic memory. Virtual reality techniques facilitate the development of ecologically valid tests. In the present study, we measure the effect of antiepileptic drug changes in a within-subject design using a virtual reality test in order to provide direct evidence for effects of antiepileptic drugs on episodic memory. Among 106 recruited patients, 97 participated in a virtual reality test up to six times during a 4-day hospitalization, and 78 patients underwent changes in drug load during this period. There were six parallel versions of a virtual town test, with immediate recall and delayed recall after about 12 h. The test requires recall of elements, details, sequence of experience, and egocentric and allocentric spatial memory. We determined drug load by defined daily dose, and compared test performance at lowest antiepileptic drug load to highest antiepileptic drug load. Across the six towns, performance was lower in delayed compared to immediate recall. There was an overall effect of medication when comparing patients taking...Continue Reading

References

Jan 1, 1983·Epilepsia·M R Trimble, P J Thompson
Feb 1, 1997·Brain : a Journal of Neurology·J S Duncan
Jul 30, 2002·Progress in Brain Research·H Stefan, E Pauli
Aug 27, 2002·Neuron·Neil BurgessJohn O'Keefe
Jul 17, 2004·Epilepsy & Behavior : E&B·Gholam K Motamedi, Kimford J Meador
Oct 19, 2004·Lancet Neurology·Christian E ElgerMartin Kurthen
Apr 12, 2005·Epilepsy & Behavior : E&B·Hennric JokeitAlois Ebner
Apr 29, 2005·Epilepsia·Josef SpattUNKNOWN Austrian Section of the International League Against Epilepsy
Nov 24, 2005·Epilepsia·Pamela J Thompson, John S Duncan
Mar 15, 2006·Epilepsia·Suncica LahLaurie Miller
Oct 19, 2006·Psychopharmacology·Sunjeev K Kamboj, H Valerie Curran
Nov 1, 2006·The European Journal of Neuroscience·Godehard Weniger, Eva Irle
Dec 6, 2007·Epilepsia·Christian HoppeChristoph Helmstaedter
Mar 6, 2008·Human Psychopharmacology·S PompéiaO F A Bueno
Apr 4, 2008·Acta Neurologica Scandinavica·J RissS Collins
Nov 26, 2009·Epilepsy & Behavior : E&B·Bruce HermannJoyce A Cramer
May 5, 2010·Neuropsychology·Gaën PlancherPascale Piolino
Aug 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·David C RowlandClifford G Kentros
Jul 31, 2012·Neuropsychologia·Chris ButlerAlan Connelly
Nov 20, 2012·Epilepsy & Behavior : E&B·Juri-Alexander Witt, Christoph Helmstaedter
Apr 26, 2013·Frontiers in Behavioral Neuroscience·Bettina M PauseEkrem Dere
Jun 14, 2013·Epilepsy & Behavior : E&B·Russell J Buono
Jun 19, 2013·Epilepsy & Behavior : E&B·Katiuska RosasJosé Manuel Cimadevilla
Sep 21, 2013·Journal of the International Neuropsychological Society : JINS·Michael B GascoigneSuncica Lah
Apr 16, 2014·Nature Reviews. Neurology·Rhys H Thomas, Samuel F Berkovic
Jul 2, 2014·Epilepsy & Behavior : E&B·Kenneth D LaxerSelim R Benbadis
Jul 30, 2015·Epilepsy Research·Virginie VoltzenlogelLiliann Manning
Aug 25, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Juri-Alexander WittChristoph Helmstaedter
Mar 10, 2016·Seizure : the Journal of the British Epilepsy Association·Christoph HelmstaedterJuri-Alexander Witt
May 18, 2016·Epileptic Disorders : International Epilepsy Journal with Videotape·Albert AldenkampMatti Sillanpää
Jul 28, 2017·The Indian Journal of Medical Research·Rupa JoshiYogendra Kumar Gupta
Aug 26, 2017·Revue neurologique·E Tramoni-NegreO Felician
Jan 25, 2018·Brain : a Journal of Neurology·Christopher D WhelanSanjay M Sisodiya
Mar 23, 2018·Multivariate Behavioral Research·Arne C BathkeYvonne Höller

❮ Previous
Next ❯

Software Mentioned

FS
SystemPlus Evolution
package
R
nparLD
UNITY
EGOCENTRIC

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.