Effects of antihypertensive drugs losartan and levamlodipine besylate on insulin resistance in patients with essential hypertension combined with isolated impaired fasting glucose

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Wei-Yin XiaoPing Wei

Abstract

The objective of this study was to observe the antihypertensive effect of losartan and levamlodipine besylate on insulin resistance in patients with essential hypertension (EH) combined with isolated impaired fasting glucose (i-IFG). Patients (n=244) were randomly assigned to losartan potassium tablets (50-100 mg per day) or levamlodipine besylate tablets (2.5-5.0 mg per day) for intensive antihypertensive treatment with no lifestyle interventions for 3 years. The changes in fasting plasma glucose, fasting insulin (FINS) and insulin sensitivity index (ISI) from before to after treatment were observed. Blood pressure (BP) in each group was significantly reduced by treatment (P<0.05). After 12 months of treatment, the FINS level in the losartan potassium group was significantly decreased and ISI was significantly increased compared with before treatment (P<0.05) and compared with the levamlodipine besylate group (P<0.05). After 24 and 36 months of treatment, FINS was significantly decreased and ISI was significantly improved in both groups compared with baseline (P<0.05), and there was no difference between the groups (P>0.05). The incidence of new-onset diabetes mellitus was not significantly different between two groups. The an...Continue Reading

References

Jul 18, 1990·JAMA : the Journal of the American Medical Association·S JuliusK Jones
Sep 5, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·N UnwinK G M M Alberti
May 7, 2004·Current Hypertension Reports·Fadi El-AtatJames R Sowers
Mar 23, 2006·Journal of the American Geriatrics Society·Nicole M van PopeleJacqueline C M Witteman
Sep 9, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Qi GuoSadayoshi Ito
Aug 14, 2012·Lancet·Ele Ferrannini, William C Cushman
Oct 12, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Daisuke UenoHironobu Yoshimatsu
Feb 14, 2013·Diabetes Care·Chanshin ParkJonathan M Samet
Feb 22, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Isao TaguchiTeruo Inoue
Sep 5, 2013·JAMA : the Journal of the American Medical Association·Yu XuUNKNOWN 2010 China Noncommunicable Disease Surveillance Group
Dec 21, 2013·Diabetes Care·UNKNOWN American Diabetes Association

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Citations

Apr 28, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hisashi Kai
Nov 30, 2018·The Cochrane Database of Systematic Reviews·Asmaa S AbdelhamidLee Hooper
Dec 7, 2018·The Cochrane Database of Systematic Reviews·Asmaa S AbdelhamidLee Hooper
Dec 13, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Stuart R Gray, Bettina Mittendorfer
Jul 9, 2020·Journal of Cardiovascular Medicine·Giuseppe DerosaArrigo F G Cicero
Jun 12, 2018·International Journal of Hypertension·Jamshed DalalArup Dasbiswas
Mar 3, 2020·The Cochrane Database of Systematic Reviews·Asmaa S AbdelhamidLee Hooper
Sep 30, 2020·Nutrients·Giuseppe DerosaEttore Novellino
Nov 19, 2020·The Journal of Pharmacology and Experimental Therapeutics·Tamara R CastañedaThomas Hübschle

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