PMID: 3741355Mar 1, 1986Paper

Effects of antioxidant therapy in experimentally induced heart infarcts

Basic Research in Cardiology
B TörökZ Pollák


Experiments were performed on dog hearts following coronary ligation and treatment with synthetic antioxidant of dihydroquinoline type. Experimental groups were: control dogs, dogs with ligation of descendens anterior coronary branch, coronary ligated dogs with antioxidant pretreatment and dogs with coronary ligation and simultaneous antioxidant infusion therapy. The heart infarction per se is accompanied by the disintegration of membrane polyunsaturated fatty acids expressed by increase of malondialdehyde (MDA) concentration and the impairment of natural scavenging characterized by the decrease of superoxide dismutase (SOD) and reduced glutathione (GSH) content. The oral pretreatment with antioxidant for 8 days prevented or decreased the unfavourable pathobiochemical responses. The acute infusion therapy exerted no immediate protection, nonetheless, it could decrease the severity of pathological signs.


Sep 8, 1978·Science·I Fridovich
Jul 1, 1979·Journal of Molecular and Cellular Cardiology·W G NaylerA Williams
Jul 1, 1978·Journal of Molecular and Cellular Cardiology·D J HearseG R Bullock
Jun 1, 1977·The American Journal of Cardiology·D J HearseS M Humphrey
Sep 1, 1985·Basic Research in Cardiology·E RöthB Matkovics
Jul 1, 1973·The American Journal of Cardiology·A SchwartzM Suzuki
Aug 1, 1983·Archives of Biochemistry and Biophysics·E OkabeH Ito
Aug 1, 1981·Journal of Molecular and Cellular Cardiology·M L HessH A Kontos
Oct 1, 1983·Journal of Molecular and Cellular Cardiology·P S RaoH S Mueller
May 1, 1984·Journal of Molecular and Cellular Cardiology·Y Gauduel, M A Duvelleroy
Nov 1, 1983·Basic Research in Cardiology·B TörökT Simor
Sep 1, 1982·Journal of Molecular and Cellular Cardiology·A V LebedevV N Smirnov
Jan 1, 1980·Advances in Lipid Research·Y A VladimirovZ P Cheremisina
Mar 1, 1982·Cardiovascular Research·Y NakamuraK Hara
Aug 1, 1980·Journal of Molecular and Cellular Cardiology·C GuarnieriC M Caldarera
Jan 1, 1981·Circulation Research·A M Katz, F C Messineo

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Jul 1, 1989·Basic Research in Cardiology·E RöthS Pollák
Jan 19, 1988·Biochimica Et Biophysica Acta·D A GamacheR C Franson
Feb 1, 1993·The International Journal of Biochemistry·T Siminiak, T Ozawa
Jul 1, 1990·Archives of Biochemistry and Biophysics·N L ParinandiH H Schmid

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