Effects of antioxidant vitamins C and E on signal-averaged electrocardiogram in acute myocardial infarction

The American Journal of Cardiology
T ChamiecL Ceremuzyński

Abstract

Experimental studies indicate that oxygen-free radicals contribute to ischemic myocardial damage and affect electric properties of cellular membranes. We hypothesize that an association exists between an oxygen-free radical-induced component of myocardial ischemic injury and altered electric function that underlies the genesis of ventricular late potentials in the course of myocardial infarction. If so, antioxidant vitamins C and E may prevent alterations in the signal-averaged electrocardiogram (SAECG). To test this hypothesis, we investigated the effect of supplementation with vitamins C and E on the indices of the SAECG in patients with acute myocardial infarction (AMI). Sixty-one patients with AMI were randomized to receive conventional treatment and vitamins C and E, each 600 mg/day, orally for 14 days (supplemented group, n = 33) or conventional treatment only (control group, n = 28). SAECG was recorded on days 1 or 2 and between days 9 and 13 (mean 10). Serum ascorbic acid, tocopherol, plasma lipid peroxides, and oxygen-free radical production by isolated leukocytes were measured on days 1 or 2 and between days 12 and 14. In the control group, SAECG showed an increase in mean QRS and low-amplitude ( < 40 microV) signal d...Continue Reading

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Citations

Jul 24, 2008·Fish Physiology and Biochemistry·N KalaimaniT C Santiago
Sep 17, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·G GuerrieroG Ciarcia
Aug 13, 2013·BioMed Research International·Ramón RodrigoDaniel Hasson
Oct 23, 2018·World Journal of Cardiology·Jaime González-MonteroRamón Rodrigo
Nov 15, 2000·International Journal of Cardiology·T RinneH G Olbrich

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