PMID: 6968724Apr 1, 1980Paper

Effects of antioxidants on lipid peroxide formation in irradiated synthetic diets

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
E D Wills

Abstract

The effect of the antoxidants, vitamin E, propyl gallate (PG), 2-t-butyl-4-methoxy phenol (BHA), 2,6-di-t-butyl-4-methoxy phenol (BHT), nordihydroguaiaretic acid (NDGA) and diphenyl-p-phenylene diamine (DPPD) in concentrations ranging between 0.001 per cent and 0.1 per cent have been tested on lipid peroxide formation in synthetic diet mixtures containing herring oil (10 per cent) mixed with starch (90 per cent) irradiated with gamma-ray doses of 100-2000 krad. On a weight basis NDGA, DPPD, BHA and BHT were most effective and vitamin E and propyl were least effective. An antioxidant concentration of 0.01 per cent normally protected against peroxide formation after a dose of 500 krad but if the dose was increased to 1000 or 2000 krad, much higher doses of antoxidant, up to 0.1 per cent, were required to give protection. Antioxidants prevented peroxide developing during post-irradiation storage even when added after irradiation. Antioxidants were partially or completely destroyed by irradiation with doses of 100 krad or more. The percentage of total antioxidant destroyed depended on the concentration; much greater destruction occurred in dilute solutions than in concentrated solutions. Vitamin E and propyl gallate were most sensi...Continue Reading

Citations

Mar 1, 1986·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J D Gower, E D Wills
Jan 1, 1997·Free Radical Biology & Medicine·A M Samuni, Y Barenholz
Mar 21, 1993·Biochimica Et Biophysica Acta·M O LongasK O Breitweiser
Jan 1, 1988·Free Radical Biology & Medicine·S N Chatterjee, S Agarwal

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