Effects of antiplatelet agents on subacute thrombosis and restenosis after successful coronary stenting: a randomized comparison of ticlopidine and cilostazol

Circulation Journal : Official Journal of the Japanese Circulation Society
Makoto SekiguchiMasahiko Kurabayashi

Abstract

A prospective randomized study compared the preventive effects of ticlopidine plus aspirin therapy versus cilostazol plus aspirin therapy on subacute thrombosis (SAT) and restenosis after coronary stenting. After successful stenting of 327 coronary lesions in 282 consecutive patients, the patients were randomized to receive ticlopidine (200 mg/day) or cilostazol (200 mg/day). Aspirin (81 mg/day) was administered concomitantly in both groups. SAT occurred in 1 patient in the ticlopidine group (0.7%) and in 8 patients in the cilostazol group (5.6%, p=0.037). Based on follow-up angiography, restenosis occurred in 30 patients (23.3%) in the ticlopidine group and 35 patients (26.9%) in the cilostazol group (NS). The late loss was significantly smaller in the cilostazol group than the ticlopidine group (1.08+/-0.95 mm vs 0.78+/-0.93 mm, respectively, p=0.037). No significant differences between the 2 groups were observed with respect to the rates of total death, non-fatal cardiovascular events, or bleeding complications. The ticlopidine group showed significantly less SAT after stenting compared with the cilostazol group. After 6 months of treatment, the inhibition of neointimal proliferation was greater in the cilostazol group than ...Continue Reading

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Citations

Sep 9, 2009·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Umesh TamhaneHitinder Gurm
Jul 1, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Noriyuki TakeyasuIwao Yamaguchi
Nov 16, 2006·International Heart Journal·Hiroshi SakamotoSeibu Mochizuki
Sep 9, 2009·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Mehmet ErgelenIbrahim Yekeler
May 15, 2007·Circulation Research·Telly A Meadows, Deepak L Bhatt
Mar 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Kenichi FukushimaIssei Komuro
May 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Joon Hoon JeongYung Woo Shin
Oct 1, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Osamu IidaSeiki Nagata
Jan 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Toshiro KatayamaKatsusuke Yano
Oct 4, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiromi YamamotoHisanori Horiuchi
Apr 30, 2011·Physiological Reviews·Sharron H FrancisJackie D Corbin
Jul 31, 2018·Current Vascular Pharmacology·Ayesha Ather, Craig J Beavers
Oct 22, 2021·Journal of Clinical Pharmacology·Antonis A ManolisAntonis S Manolis

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