Effects of antiplatelet drugs on dialysis-associated platelet deposition in polytetrafluoroethylene grafts

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
D W WindusH D Royal

Abstract

Hemodialysis is associated with platelet deposition in polytetrafluoroethylene (PTFE) graft fistulas. We determined whether aspirin or ticlopidine would modify this response. Patients on chronic hemodialysis with forearm loop PTFE fistulas were studied. Platelets labeled with 111indium were injected and a baseline scan of the fistula arm was made with a large field of view gamma camera. After a routine dialysis treatment, a second scan was performed within 1 hour. Four weeks later, a repeat labeled platelet study was conducted after taking either aspirin 325 mg/d or ticlopidine 250 mg/d orally for 7 days. Images were computer analyzed by drawing seven standardized regions along each graft. The counts per second per pixel in postdialysis images were compared with predialysis images for each region and a percent uptake compared with the predialysis image was calculated. Regions with dialysis-induced uptake of more than 1.5-fold compared with the predialysis image before antiplatelet drug therapy were compared with these same regions after therapy. Six patients were studied before and after aspirin therapy. Uptakes larger than 1.5-fold over predialysis images were found in 12 of 40 regions and were 292% +/- 50% (+/-SEM) before and...Continue Reading

Citations

Nov 10, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J H SmitsT J Rabelink
Jul 31, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·R Vanholder
Dec 7, 2011·Angiology·Kosmas I ParaskevasAthanasios D Giannoukas
May 15, 2003·Scandinavian Journal of Urology and Nephrology·Chamberlain I ObialoLinda F Lebon
Dec 12, 2001·Kidney International·D J Goldsmith, A Covic
May 7, 1999·Kidney International·S J SchwabD Beasley

Related Concepts

Arteriovenous Anastomosis Procedure
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Hemodialysis
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Kidney Failure, Chronic
Platelet Adhesiveness
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Platelet Inhibitors
Tarflen

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