Effects of applied electric fields on clinical cases of complete paraplegia in dogs

Restorative Neurology and Neuroscience
R B BorgensJ R Cook

Abstract

A clinical trial of applied, slowly oscillating, weak electric fields was performed in dogs with naturally occurring spinal cord injuries due to intervertebral disc herniation. Criteria for admission to the study were: complete paraplegia, defined by neurological examination and electrophysiological testing; intact segmental reflexes; radiologic and myelographic evidence of spinal cord compression due to disc herniation and a focal lesion, without appreciable rostrocaudal spread of necrosis; weight less than 16 kg; onset of paralysis less than 1 month before surgery. The injured cord was exposed by laminectomy, and decompressed by aspiration of disc material. Active (n = 13) or sham (n = 11) stimulators were implanted subcutaneously, with platinum/iridium electrodes sutured to muscle several millimeters above the cord surface, at either end of the laminectomy site. Active stimulators delivered 200 μA of direct current, switching polarity every 15 min, for 3, 6, or 15 weeks. Neurological and electrophysiological examinations were repeated approximately 6 weeks and 6 months after implantation. Few complications were noted. None were attributable to current application. The group of dogs with active stimulators showed greater impr...Continue Reading

Citations

Jan 22, 2005·Journal of Neurosurgery. Spine·Scott ShapiroPaul Nelson
Aug 5, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Samar Hamid, Ray Hayek
Mar 29, 2011·Journal of Neurotrauma·Jonathan M LevineLinda J Noble-Haeusslein
May 23, 2020·Journal of Neurotrauma·Andrew S JackKarim Fouad
Dec 19, 2014·The International Journal of Neuropsychopharmacology·Simon J Pelletier, Francesca Cicchetti
Jan 8, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R B Borgens, R Shi
Jul 1, 2005·Physiological Reviews·Colin D McCaigMin Zhao
Nov 17, 2020·Frontiers in Veterinary Science·Melissa J LewisUNKNOWN Canine Spinal Cord Injury Consortium (CANSORT-SCI)

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