Effects of aqueous extract of Portulaca oleracea L. on oxidative stress and liver, spleen leptin, PARα and FAS mRNA expression in high-fat diet induced mice.

Molecular Biology Reports
Bendong ChenGuangshun Yang

Abstract

We reported that an aqueous extract of Portulaca oleracea L. inhibited high-fat-diet-induced oxidative injury in a dose-dependent manner. Male kunming mice (5-weeks-old, 24 g) were used in this experiment. After a 4-day adaptation period, animals were randomly divided into four groups (n = 10 in each group); Group 1: animals received normal powdered rodent diet; Group 2: animals received high fat diet; Groups 3 and 4: animals received high fat diet and were fed by gavage to mice once a day with aqueous extract at the doses of 100 and 200 mg/kg body weight, respectively. In mice fed with high-fat diet, blood and liver lipid peroxidation level was significantly increased, whereas antioxidant enzymes activities were markedly decreased compared to normal control mice. Administration of an aqueous extract of P. oleracea L. significantly dose-dependently reduced levels of blood and liver lipid peroxidation and increased the activities of blood and liver antioxidant enzymes activities in high fat mice. Moreover, administration of an aqueous extract of P. oleracea L. significantly dose-dependently increase liver Leptin/β-actin (B), and Liver PPARα/β-actin, decrease liver, spleen FAS mRNA, p-PERK and p-PERK/PERK protein expression level...Continue Reading

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Citations

Mar 31, 2018·Current Drug Discovery Technologies·Tahereh FarkhondehSoroush Hozeifi
Nov 4, 2016·Natural Product Research·Liang XuJing Liu
Dec 13, 2017·Journal of Evidence-based Complementary & Alternative Medicine·Saeed SamarghandianTahereh Farkhondeh
Jan 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vafa Baradaran RahimiVahid Reza Askari
Feb 19, 2015·BioMed Research International·Yan-Xi ZhouHong Zhang
Jul 12, 2016·Journal of Agricultural and Food Chemistry·Cui-Yu LiXi-Xiang Ying
Jun 8, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yun HuangJu-Hui Zhao

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