Effects of arginine vasotocin and mesotocin on the activation and development of amiloride-blockable short-circuit current across larval, adult, and cultured larval bullfrog skins.

Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
Makoto TakadaShigeru Hokari

Abstract

Amphibian skin has osmoregulatory functions, with Na(+) crossing from outside to inside. Na(+) transport can be measured as the short-circuit current (SCC). We investigated the short-term and long-term effects of arginine vasotocin (AVT) and mesotocin (MT) (which modulate Na(+) transport) on the activation and development of an amiloride-blockable SCC (adult-type feature) in larval, adult, and corticoid-cultured larval bullfrog skins. We found: (1) AVT-receptor (AVT-R) and MT-receptor (MT-R) mRNAs could be detected in both larval and adult skins, (2) in the short term (within 60 min), the larval SCC (amiloride-stimulated SCC) was increased by AVT, forskolin, and MT, suggesting that AVT and MT did not activate the inactive ENaC (epithelial sodium channel) protein thought to be expressed in larval skin, (3) in the short term (within 90 min), AVT, forskolin, and MT stimulated the adult SCC (amiloride-blockable SCC), (4) AVT and MT increased both the larval and adult SCC via receptors insensitive to OPC-21268 (an antagonist of the V(1)-type receptor), OPC-31260 (an antagonist of the V(2)-type receptor), and ([d(CH(2))(5),Tyr(Me)(2),Thr(4),Orn(8),des-Gly-NH (2) (9) ]VT) (an antagonist of the oxytocin receptor), (5) culturing EDTA-tr...Continue Reading

References

Jul 1, 1979·The American Journal of Physiology·T C Cox, R H Alvarado
May 1, 1991·The American Journal of Physiology·Y Marunaka, D C Eaton
Jan 1, 1989·The American Journal of Physiology·S D Hillyard, W Van Driessche
Mar 1, 1987·The Anatomical Record·D H Robinson, M B Heintzelman
Mar 1, 1994·The American Journal of Physiology·T R KleymanB Coupaye-Gerard
Jan 1, 1993·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·M Takada
Oct 1, 1996·The American Journal of Physiology·M TakadaS Komazaki
Jan 31, 1998·The Journal of Biological Chemistry·S DjelidiM Blot-Chabaud
Apr 16, 1998·Regulatory Peptides·C H Hoyle
Jul 15, 2000·American Journal of Physiology. Renal Physiology·C A EcelbargerM A Knepper
Jun 28, 2002·Physiological Reviews·Stephan Kellenberger, Laurent Schild
Nov 26, 2005·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Makoto TakadaThomas C Cox
Jan 1, 1946·The Anatomical Record·A C TAYLOR, J J KOLLROS

❮ Previous
Next ❯

Citations

Oct 29, 2010·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Makoto TakadaShigeru Hokari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
D HolbirdT Cox
Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
Makoto Takada
Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
Makoto TakadaT Cox
Pflügers Archiv : European journal of physiology
W Nagel, J Crabbé
© 2022 Meta ULC. All rights reserved