Effects of aripiprazole and haloperidol on neural activation during the n-back in healthy individuals: A functional MRI study.

Schizophrenia Research
Rhianna GoozeePaola Dazzan

Abstract

Antipsychotic drugs target neurotransmitter systems that play key roles in working memory. Therefore, they may be expected to modulate this cognitive function via their actions at receptors for these neurotransmitters. However, the precise effects of antipsychotic drugs on working memory function remain unclear. Most studies have been carried out in clinical populations, making it difficult to disentangle pharmacological effects from pathology-related brain activation. In this study, we aim to investigate the effects of two antipsychotic compounds on brain activation during working memory in healthy individuals. This would allow elucidation of the effects of current antipsychotic treatments on brain function, independently of either previous antipsychotic use or disease-related pathology. We carried out a fully counterbalanced, randomised within-subject, double-blinded and placebo-controlled, cross-over study of the effects of two antipsychotic drugs on working memory function in 17 healthy individuals, using the n-back task. Participants completed the functional MRI task on three separate occasions (in randomised order): following placebo, haloperidol, and aripiprazole. For each condition, working memory ability was investigat...Continue Reading

Citations

Sep 4, 2015·Clinical Neuroradiology·H LanfermannP Raab
Dec 21, 2018·Frontiers in Psychiatry·Nicole E MacKenzieMargaret K Hahn

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